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额部和尾部前肢皮质脊髓神经元群体的拓扑和细胞类型特异性连接。

Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.

机构信息

Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.

Allen Institute for Brain Science, Allen Institute, Seattle, WA, USA.

出版信息

Cell Rep. 2024 Apr 23;43(4):113993. doi: 10.1016/j.celrep.2024.113993. Epub 2024 Mar 27.

DOI:10.1016/j.celrep.2024.113993
PMID:38551963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11100358/
Abstract

Corticospinal neurons (CSNs) synapse directly on spinal neurons, a diverse assortment of cells with unique structural and functional properties necessary for body movements. CSNs modulating forelimb behavior fractionate into caudal forelimb area (CFA) and rostral forelimb area (RFA) motor cortical populations. Despite their prominence, the full diversity of spinal neurons targeted by CFA and RFA CSNs is uncharted. Here, we use anatomical and RNA sequencing methods to show that CSNs synapse onto a remarkably selective group of spinal cell types, favoring inhibitory populations that regulate motoneuron activity and gate sensory feedback. CFA and RFA CSNs target similar spinal neuron types, with notable exceptions that suggest that these populations differ in how they influence behavior. Finally, axon collaterals of CFA and RFA CSNs target similar brain regions yet receive highly divergent inputs. These results detail the rules of CSN connectivity throughout the brain and spinal cord for two regions critical for forelimb behavior.

摘要

皮质脊髓神经元 (CSNs) 直接与脊髓神经元突触，脊髓神经元是具有独特结构和功能特性的多种细胞，对于身体运动是必需的。调节前肢行为的 CSNs 分为后肢前肢区 (CFA) 和前肢前肢区 (RFA) 运动皮质群体。尽管它们很突出，但 CFA 和 RFA CSNs 靶向的脊髓神经元的全部多样性仍未被绘制。在这里，我们使用解剖学和 RNA 测序方法表明，CSNs 与一组非常选择性的脊髓细胞类型形成突触，偏爱调节运动神经元活动和门控感觉反馈的抑制性群体。CFA 和 RFA CSNs 靶向相似的脊髓神经元类型，但也有明显的例外，表明这些群体在影响行为方面存在差异。最后，CFA 和 RFA CSNs 的轴突侧支靶向相似的脑区，但接收高度不同的输入。这些结果详细描述了两个对前肢行为至关重要的区域中整个大脑和脊髓中 CSN 连接的规则。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/efc231a4f405/nihms-1988739-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/6b8c218ddcee/nihms-1988739-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/b84f0843faba/nihms-1988739-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/292ae5e8a27c/nihms-1988739-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/efc231a4f405/nihms-1988739-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/6b8c218ddcee/nihms-1988739-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/b84f0843faba/nihms-1988739-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/292ae5e8a27c/nihms-1988739-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b1/11100358/efc231a4f405/nihms-1988739-f0004.jpg

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