Cheung Pak-Hin Hinson, Yang Hua, Wu Li
Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
J Virol. 2025 May 20;99(5):e0030225. doi: 10.1128/jvi.00302-25. Epub 2025 Apr 25.
SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.
SAMHD1是哺乳动物细胞中的一种脱氧核糖核苷酸三磷酸酶。2011年，SAMHD1被发现是一种通过减少脱氧核糖核苷酸三磷酸来对抗逆转录病毒的宿主限制因子。最近的研究表明，SAMHD1的抗病毒机制不能仅仅用其脱氧核糖核苷酸三磷酸酶活性来解释。相反，SAMHD1介导的对多种病毒的限制的多样性表明其抗病毒机制超出了脱氧核糖核苷酸三磷酸的消耗。这解释了SAMHD1在先天抗病毒免疫中发挥重要作用的多方面和广泛的限制功能。
