Parreira Maria Júlia Bento Martins, Buchaim Daniela Vieira, Bighetti Ana Carolina Cestari, Girotto Marcos Antonio, de Marchi Miguel Ângelo, Nogueira Dayane Maria Braz, Foggiato Augusto Alberto, Coléte Juliana Zorzi, Fuziy Acácio, Buchaim Rogerio Leone
Postgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, Brazil.
Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science (FMVZ/USP), University of Sao Paulo, Sao Paulo 05508-270, Brazil.
Dent J (Basel). 2025 Mar 25;13(4):142. doi: 10.3390/dj13040142.
Rapid palatal expansion is commonly used to correct maxillary deficiencies. However, medications like Isotretinoin may influence bone remodeling during treatment. Isotretinoin, a drug used to treat acne, was the focus of this study, which aimed to evaluate its effect on bone repair after rapid palatal suture expansion in rats. The sample consisted of 40 Wistar rats, divided into two groups: the control group (CG), subjected only to orthodontic movement, and the experimental isotretinoin group (IG), where movement occurred after drug administration. Periods of 0, 7, and 14 days after the installation of the orthodontic device were analyzed, with a force of 30 g applied in all groups using a steel spring. After euthanasia, the maxillae were removed and analyzed via Micro-CT, histologically, and histomorphometrically. The results showed that the expander was effective in promoting the expansion of the palatal suture. After 14 days, the total expansion was 381% (CG) and 299% (IG); the percentage of vessels in the connective tissue increased by 145% in CG and 84% in IG; and bone formation in both groups occupied 52% of the expanded palatal suture. No significant differences were observed between the groups regarding collagen fiber formation. It was concluded that the daily administration of Isotretinoin at the standard dose for the treatment of severe acne does not cause significant alterations in the bone repair process following the opening of the median palatine suture in rats.
快速腭扩展常用于纠正上颌骨发育不足。然而，异维A酸等药物可能会在治疗过程中影响骨重塑。异维A酸是一种用于治疗痤疮的药物，是本研究的重点，该研究旨在评估其对大鼠快速腭中缝扩展后骨修复的影响。样本包括40只Wistar大鼠，分为两组：对照组（CG），仅接受正畸移动；实验性异维A酸组（IG），在给药后进行移动。分析了正畸装置安装后0、7和14天的时间段，所有组均使用钢弹簧施加30 g的力。安乐死后，取出上颌骨并通过微型计算机断层扫描、组织学和组织形态计量学进行分析。结果表明，扩张器有效地促进了腭中缝的扩展。14天后，总扩展率在CG组为381%，在IG组为299%；结缔组织中血管的百分比在CG组增加了145%，在IG组增加了84%；两组中的骨形成均占扩展腭中缝的52%。在胶原纤维形成方面，两组之间未观察到显著差异。得出的结论是，以治疗重度痤疮的标准剂量每日服用异维A酸，不会在大鼠腭中缝打开后引起骨修复过程的显著改变。
