The Whitening Efficacy of a Hydroxyapatite Toothpaste and a Blue Covarine Toothpaste: A Comparative In Vitro Study.

: There is high demand for white and healthy teeth. Therefore, various whitening toothpastes are commercially available. Hydroxyapatite and blue covarine are two ingredients used in whitening toothpaste formulations. : This in vitro study analyzed the stain-removing efficacy of two commercial whitening toothpastes: one containing hydroxyapatite and the other containing blue covarine. : The stain-removing efficacy of both toothpastes was analyzed for different brushing times (30 and 180 s) using a staining model on human enamel. Photographic documentation and colorimetric measurements were performed after staining and after each brushing series. Colorimetric measurements were used to determine the stain removal efficacy in percentage. Statistical analysis was performed using one-way analysis of variance (ANOVA) with a post hoc Tukey test and Levene's test to assess the homogeneity of variances. The significance level α was set at 0.05. : The hydroxyapatite toothpaste demonstrated a significantly higher stain-removing efficacy compared to the blue covarine toothpaste after 30 s of brushing. The stain-removing efficacy was comparable between the two toothpastes after 180 s of brushing. : Both hydroxyapatite and blue covarine toothpastes effectively cleaned stained enamel, with hydroxyapatite toothpaste showing a significantly higher stain-removing efficacy after 30 s of brushing.