Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Unilever Oral Care,66 Linxin Road, Changning District, Shanghai 200335, China.
J Dent. 2017 Dec;67S:S25-S28. doi: 10.1016/j.jdent.2017.08.014. Epub 2017 Aug 30.
To measure tooth whitening effects delivered immediately after brushing with silica-based toothpastes containing either blue covarine or a combination of blue covarine and FD&C Blue No. 1 in vitro and in vivo.
Salivary pellicle coated human extracted teeth were brushed with either a slurry of a toothpaste containing blue covarine (BC) or a formulation containing a matched level of blue covarine and FD&C Blue No.1 (BC+D). The colour of the specimens were measured in vitro using a colorimeter, before and after brushing and changes in CIELAB and tooth Whiteness Index (WIO) values calculated. In a double-blind cross-over clinical study, subjects brushed with BC toothpaste, a toothpaste containing increased levels of blue covarine (BC+) or BC+D toothpaste and tooth colour changes were measured with a digital image analysis system.
The in vitro study demonstrated that BC+D gave a significantly (p=0.002) greater change in WIO value than BC. Clinical results showed that BC, BC+ and BC+D gave a significant increase in WIO (p<0.0001) from baseline. The WIO change was significantly greater when brushing with BC+D toothpaste than with either toothpaste BC (p<0.0001) or BC+ (p<0.05).
Toothpastes containing blue covarine or a combination of blue covarine and FD&C Blue No. 1 gave a statistically significant improvement in tooth whiteness immediately after brushing in both in vitro and clinical studies. In addition, the toothpaste containing both blue covarine and FD&C Blue No. 1 gave statistically significant greater tooth whitening from baseline than the blue covarine containing toothpastes.
The silica-based toothpastes containing blue covarine or a combination of blue covarine and FD&C Blue No. 1 evaluated in the current study gave significant tooth whitening benefits immediately after one brush.
测量含有蓝 Covarine 的硅基牙膏或含有蓝 Covarine 和 FD&C 蓝色 1 号的硅基牙膏在刷牙后即刻提供的牙齿美白效果，在体外和体内进行。
用含有蓝 Covarine（BC）的牙膏浆或含有等量蓝 Covarine 和 FD&C 蓝色 1 号的配方（BC+D）的配方刷牙，在体外使用比色计测量牙釉质涂层的人牙样本的颜色，在刷牙前后测量颜色变化，并计算 CIELAB 和牙齿美白指数（WIO）值的变化。在一项双盲交叉临床试验中，受试者用 BC 牙膏、含有较高水平蓝 Covarine 的牙膏（BC+）或 BC+D 牙膏刷牙，并使用数字图像分析系统测量牙齿颜色变化。
体外研究表明，BC+D 牙膏在 WIO 值上的变化明显大于 BC（p=0.002）。临床结果表明，BC、BC+和 BC+D 从基线开始均使 WIO 显著增加（p<0.0001）。用 BC+D 牙膏刷牙时，WIO 的变化明显大于 BC 牙膏（p<0.0001）或 BC+牙膏（p<0.05）。
含有蓝 Covarine 或蓝 Covarine 和 FD&C 蓝色 1 号混合物的牙膏在体外和临床研究中均能显著改善刷牙后即刻的牙齿美白效果。此外，含有蓝 Covarine 和 FD&C 蓝色 1 号的牙膏与含有蓝 Covarine 的牙膏相比，从基线开始的牙齿美白效果有统计学意义上的显著提高。
在当前研究中评估的含有蓝 Covarine 或蓝 Covarine 和 FD&C 蓝色 1 号混合物的硅基牙膏在一次刷牙后立即提供了显著的牙齿美白益处。
