Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
J Dent. 2019 Sep;88:103170. doi: 10.1016/j.jdent.2019.07.008. Epub 2019 Jul 17.
This network meta-analysis compares different desensitizing toothpastes and placebo in terms of their effects on dentine hypersensitivity (DH) at 2, 4, and 8 weeks.
A systematic electronic literature search of four databases, and a manual search, were performed to identify randomized controlled trials (RCTs) on different desensitizing toothpastes for the treatment of DH. Pair-wise and network meta-analyses were performed to analyze the desensitization effect at 2, 4, and 8 weeks. The risk of bias was assessed based on the Cochrane guidelines and funnel plots. Statistical heterogeneity, inconsistencies, and ranking probability were also evaluated.
A total of 30 RCTs were included in the network meta-analysis, which included eight desensitizing toothpastes. There was no significant difference in the effect among calcium sodium phosphosilicate-containing (CSPS), potassium-containing (K) and strontium-containing (Sr) toothpastes. In addition, there was no significant difference between fluoride (F) and placebo. The desensitizing toothpaste with the highest probability of being the most effective treatment for DH was nano-hydroxyapatite (n-HA) at 2 and 4 weeks (60% and 67%, respectively), and Ar at 8 weeks (54%).
No significant difference was detected in desensitizing effects among CSPS, K and Sr toothpastes. In addition, there was no significant difference between F and placebo, K and placebo. Furthermore, a significant placebo effect on DH was found in this study. Moreover, n-HA toothpastes may be the best desensitizing toothpastes for treatment of DH, followed by Ar toothpaste.
Based on the results of present network meta-analysis, n-HA containing toothpastes might be a recommended desensitizing toothpastes considering the treatment of DH. PROSPERO registration number: CRD42019117710.
本网络荟萃分析比较了不同脱敏牙膏和安慰剂在治疗牙本质敏感症（DH）方面的 2、4 和 8 周的效果。
通过对四个数据库的系统电子文献检索和手动检索，确定了用于治疗 DH 的不同脱敏牙膏的随机对照试验（RCT）。进行了两两和网络荟萃分析，以分析 2、4 和 8 周时的脱敏效果。根据 Cochrane 指南和漏斗图评估偏倚风险。还评估了统计异质性、不一致性和排序概率。
共有 30 项 RCT 纳入网络荟萃分析，包括 8 种脱敏牙膏。含硅酸钙钠（CSPS）、钾（K）和锶（Sr）的牙膏在效果上无显著差异。此外，氟化物（F）与安慰剂也无显著差异。在治疗 DH 方面，最有可能是最有效治疗的脱敏牙膏在 2 和 4 周时是纳米羟基磷灰石（n-HA）（分别为 60%和 67%），在 8 周时是 Ar（54%）。
在 CSPS、K 和 Sr 牙膏的脱敏效果方面未发现显著差异。此外，F 和安慰剂、K 和安慰剂之间也无显著差异。此外，本研究发现 DH 存在显著的安慰剂效应。此外，n-HA 牙膏可能是治疗 DH 的最佳脱敏牙膏，其次是 Ar 牙膏。
根据本网络荟萃分析的结果，考虑到 DH 的治疗，含 n-HA 的牙膏可能是一种推荐的脱敏牙膏。PROSPERO 注册号：CRD42019117710。
