Bertulla Elisa, Diaz Raquel, Mascherini Matteo, Casaccia Marco, Depaoli Francesca, Cuniolo Letizia, Cornacchia Chiara, Margarino Cecilia, Murelli Federica, Franchelli Simonetta, Pesce Marianna, Boccardo Chiara, Gipponi Marco, De Cian Franco, Fregatti Piero
Department of Surgical and Diagnostic Integrated Sciences-DISC, University of Genova, 16132 Genova, Italy.
Surgical Cinical Unit 1, Department of Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Curr Oncol. 2025 Apr 10;32(4):218. doi: 10.3390/curroncol32040218.
The association between breast cancer and non-Hodgkin lymphoma of the spleen is extremely rare, with very few cases documented in the medical literature. We present the case of a 39-year-old woman in good health but with a family history of breast cancer, who, in 2017, developed invasive lobular carcinoma in her right breast, which was treated with mastectomy followed by hormonal therapy. In 2024, she presented with a suspicious right axillary mass, suspected of recurrence, which was confirmed by fine-needle aspiration biopsy. The patient received neoadjuvant chemotherapy, followed by axillary lymph node dissection and bilateral adnexectomy. CT and PET scans showed suspicious splenic lesions suggestive of metastases. Infectious and hematological tests were negative, leading to the decision to perform laparoscopic splenectomy. Histological examination revealed follicular B-cell non-Hodgkin lymphoma. The patient is now in good general condition and is on a biannual follow-up. The case highlights the diagnostic complexity of tumor recurrences and the need to consider alternative diagnoses other than metastasis in oncological patients.
乳腺癌与脾脏非霍奇金淋巴瘤之间的关联极为罕见，医学文献中记载的病例极少。我们报告一例39岁健康女性病例，该女性有乳腺癌家族史，2017年其右乳发生浸润性小叶癌，接受了乳房切除术及后续激素治疗。2024年，她出现右侧腋窝可疑肿块，怀疑复发，细针穿刺活检予以证实。患者接受了新辅助化疗，随后进行腋窝淋巴结清扫和双侧附件切除术。CT和PET扫描显示脾脏有可疑病变，提示转移。感染和血液学检查均为阴性，因此决定行腹腔镜脾切除术。组织学检查显示为滤泡性B细胞非霍奇金淋巴瘤。患者目前总体状况良好，每半年接受一次随访。该病例凸显了肿瘤复发的诊断复杂性，以及肿瘤患者除转移外需考虑其他诊断的必要性。
