Garbin Elisa, Nicolè Lorenzo, Magrini Salima, Ceccaroni Yuri, Denaro Luca, Basaldella Luca, Rossetto Marta
Academic Neurosurgery, Department of Neurosciences, University of Padova, 35128 Padova, PD, Italy.
Unit of Pathology, Angel Hospital, 30174 Mestre, VE, Italy.
Curr Oncol. 2025 Apr 21;32(4):242. doi: 10.3390/curroncol32040242.
Glioblastoma in patients affected by NF1 germline mutation (NF1-associated GBM) represents a unique heterogeneous clinical and pathological entity. We have reviewed the few cases reported in the literature and they seem to have a better response to standard therapy and overall survival than GBM in the non-NF1 population. We present two cases of long-survival NF1 patients with GBM. Case 1 was a 38-year-old woman with cerebellar GBM who underwent surgical asportation and the Stupp protocol many times with an overall survival of 117 months. Case 2 was a 47-year-old woman with GBM in the eloquent area of the right frontal lobe; she underwent surgical asportation and the Stupp protocol with an overall survival of 25 months. The data analysis demonstrates that NF1-associated GBM patients could be considered long-term survivors.
患有NF1种系突变的患者中的胶质母细胞瘤（NF1相关胶质母细胞瘤）是一种独特的异质性临床和病理实体。我们回顾了文献中报道的少数病例，与非NF1人群中的胶质母细胞瘤相比，它们似乎对标准治疗和总生存期有更好的反应。我们介绍了两例长期存活的NF1相关胶质母细胞瘤患者。病例1是一名38岁患有小脑胶质母细胞瘤的女性，她多次接受手术切除和Stupp方案治疗，总生存期为117个月。病例2是一名47岁患有右侧额叶功能区胶质母细胞瘤的女性；她接受了手术切除和Stupp方案治疗，总生存期为25个月。数据分析表明，NF1相关胶质母细胞瘤患者可被视为长期存活者。
