Tóth Zoltán, Ványai Beatrix, Kovács Renátó, Jakab Ágnes, Szegedi Andrea, Balázs Bence, Majoros László
Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Medical Microbiology, Clinical Centre, University of Debrecen, 4032 Debrecen, Hungary.
J Fungi (Basel). 2025 Mar 25;11(4):248. doi: 10.3390/jof11040248.
is associated with difficult-to-treat, often extensive dermatophytosis and resistance to the commonly used antifungal agents. Successful therapy often necessitates higher than usual doses of systemic therapy for prolonged periods. The spread of this species has gained much attention lately, as several European and other Western hemisphere countries have recently reported their first respective cases or increasing numbers of them. Until recently, this species was not described in Hungary. Here, we report a case caused by this species in a patient with a travel history to an endemic region. The isolate was identified preliminarily by MALDI-TOF mass spectrometry and confirmed by DNA sequencing; furthermore, it was subject to phenotypic antifungal susceptibility testing by broth microdilution to fluconazole, voriconazole, posaconazole, itraconazole, and terbinafine. According to the susceptibility results, the isolate was wild type to all tested agents, including terbinafine which was in line with the sequencing data, and with the uncommon excellent therapeutic response to topical allylamine treatment. This case also further confirms the applicability of the MSI-2 database for the rapid identification of in routine clinical microbiology laboratories as a cost-effective and simple method.
与难以治疗、通常广泛的皮肤癣菌病以及对常用抗真菌药物的耐药性有关。成功的治疗通常需要长时间使用高于常规剂量的全身治疗。由于几个欧洲和其他西半球国家最近分别报告了首例病例或病例数量增加,该菌种的传播最近受到了广泛关注。直到最近,匈牙利才报道了该菌种。在此,我们报告一例由该菌种引起的病例,患者有前往流行地区的旅行史。该分离株首先通过基质辅助激光解吸电离飞行时间质谱(MALDI-TOF)进行初步鉴定,然后通过DNA测序进行确认;此外,通过肉汤微量稀释法对氟康唑、伏立康唑、泊沙康唑、伊曲康唑和特比萘芬进行了表型抗真菌药敏试验。根据药敏结果,该分离株对所有测试药物均为野生型,包括特比萘芬,这与测序数据一致,并且对局部用烯丙胺治疗有罕见的良好治疗反应。该病例还进一步证实了MSI-2数据库在常规临床微生物实验室中作为一种经济有效且简单的方法用于快速鉴定的适用性。