基因编辑：发展、挑战与未来前景
Gene Editing in : Development, Challenges, and Future Prospects.
作者信息
He Shiqi, Liu Yuanchao, Zhang Zhi, Cai Manjun, Hao Yufan, Hu Huiping
机构信息
National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Guangdong Yuewei Biotechnology Co., Ltd., Shaoguan 512029, China.
出版信息
J Fungi (Basel). 2025 Apr 14;11(4):310. doi: 10.3390/jof11040310.
As an emerging and innovative technology, gene-editing technology has been widely applied in crop breeding, human disease treatment, animal model research, drug and vaccine development, and microbial engineering. We mainly introduce the development of gene-editing technology, the application of clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) in breeding, the current challenges and optimization strategies in the use of gene-editing technology in breeding, as well as the current status of gene-editing technology in breeding. Finally, the future research directions and innovative strategies that gene editing may explore in breeding are prospects given the existing background, future research directions, and innovative strategies that gene editing may explore in breeding prospects.
作为一项新兴的创新技术，基因编辑技术已广泛应用于作物育种、人类疾病治疗、动物模型研究、药物和疫苗开发以及微生物工程。我们主要介绍基因编辑技术的发展、成簇规律间隔短回文重复序列/Cas9（CRISPR/Cas9）在育种中的应用、基因编辑技术在育种应用中的当前挑战和优化策略，以及基因编辑技术在育种中的现状。最后，鉴于现有背景，给出了基因编辑在育种中可能探索的未来研究方向和创新策略，基因编辑在育种中可能探索的未来研究方向和创新策略展望。
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