Kerlikowsky Felix, Bartsch Madeline, Jonas Wiebke, Hahn Andreas, Schuchardt Jan Philipp
Institute of Food Science and Human Nutrition, Leibniz University Hannover, Am Kleinen Felde 30, 30159 Hannover, Germany.
NutritionLab, Faculty of Agricultural Sciences and Landscape Architecture, Osnabrueck University of Applied Sciences, 49090 Osnabrueck, Germany.
Mar Drugs. 2025 Mar 23;23(4):139. doi: 10.3390/md23040139.
Obesity increases the risk for insulin resistance (IR) and type-2 diabetes. Lifestyle interventions (LI) and dietary supplementation can help mitigate IR. We investigated the effect of calanus oil (CO) supplementation, combined with LI, on glucose homeostasis in obese subjects. CO, a novel marine oil, contains omega-3 fatty acid wax esters as well as plant sterols and astaxanthin. In the double-blind, randomized, placebo-controlled 12-week intervention study, 266 subjects with distinct IR phenotypes were assigned to four groups: 2 g CO/day, 4 g CO/day, 2 g CO/day + LI, and placebo. The effect of CO on HOMA index reduction was influenced by the initial (t) squared HOMA index (interaction = 0.011). A post hoc test showed significant improvement with 2 g CO/day + LI (estimated marginal means [EMM] 95% confidence interval [CI]: -0.19 [-0.80-0.41], = 0.021). Secondary analysis revealed that 4 g CO/day had significant effects in subjects with mild IR (HOMA index 2.5-5.0) (EMM [95% CI]: -0.76 [-1.53-0.03], = 0.043). CO supplementation improved glucose homeostasis, with effects varying by dose, combination with LI, and IR phenotype.
肥胖会增加胰岛素抵抗（IR）和2型糖尿病的风险。生活方式干预（LI）和膳食补充剂有助于减轻IR。我们研究了补充卡露鳕鱼油（CO）并结合LI对肥胖受试者葡萄糖稳态的影响。CO是一种新型海洋油，含有ω-3脂肪酸蜡酯以及植物甾醇和虾青素。在这项双盲、随机、安慰剂对照的12周干预研究中，266名具有不同IR表型的受试者被分为四组：每天2克CO、每天4克CO、每天2克CO + LI以及安慰剂组。CO对稳态模型评估（HOMA）指数降低的影响受初始（t）平方HOMA指数的影响（交互作用 = 0.011）。事后检验显示，每天2克CO + LI有显著改善（估计边际均值[EMM] 95%置信区间[CI]：-0.19 [-0.80 - 0.41]，P = 0.021）。二次分析显示，每天4克CO对轻度IR（HOMA指数2.5 - 5.0）的受试者有显著影响（EMM [95% CI]：-0.76 [-1.53 - 0.03]，P = 0.043）。补充CO改善了葡萄糖稳态，其效果因剂量、与LI的组合以及IR表型而异。
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