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免疫功能正常的成年人由[未提及具体病因]引起的骨髓炎:病例报告及文献综述

Osteomyelitis Caused by in an Immunocompetent Adult: A Case Report and Literature Review.

作者信息

Chen Yi-Ying, Yeh Ting-Kuang, Wu Chi-Jung, Liu Po-Yu

机构信息

Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.

Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.

出版信息

Trop Med Infect Dis. 2025 Apr 14;10(4):107. doi: 10.3390/tropicalmed10040107.

Abstract

Osteomyelitis caused by is exceedingly rare and, to our knowledge, has not been previously reported in immunocompetent individuals. This case represents the first documented instance. A 19-year-old woman developed osteomyelitis following an open right leg fracture sustained in a traffic accident. Initial cultures yielded an unidentified yeast, later identified as through internal transcribed spacer sequencing. The patient demonstrated clinical improvement with combination therapy of amphotericin B and following oral voriconazole. This case underscores the emerging pathogenic potential of spp., particularly in the setting of trauma and open wounds, and highlights the importance of including this genus in the differential diagnosis of osteomyelitis. A literature review indicates that infections are predominantly observed in immunocompromised patients, especially in Asia. However, our case underscores the need for greater awareness of this emerging pathogen in immunocompetent hosts as well.

摘要

由 引起的骨髓炎极为罕见,据我们所知,此前在免疫功能正常的个体中尚未有过报道。该病例是首例有记录的病例。一名19岁女性在交通事故中右腿开放性骨折后发生骨髓炎。初始培养物分离出一种未鉴定的酵母菌,后来通过内部转录间隔区测序鉴定为 。患者接受两性霉素B联合口服伏立康唑治疗后临床症状改善。该病例强调了 属真菌新出现的致病潜力,特别是在创伤和开放性伤口的情况下,并突出了在骨髓炎鉴别诊断中考虑该属真菌的重要性。文献综述表明, 感染主要见于免疫功能低下的患者,尤其是在亚洲。然而,我们的病例也强调了在免疫功能正常的宿主中也需要提高对这种新出现病原体的认识。

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