Natarajan N, Nemoto T, Mettlin C, Murphy G P
Cancer. 1985 Oct 1;56(7):1704-9. doi: 10.1002/1097-0142(19851001)56:7<1704::aid-cncr2820560740>3.0.co;2-l.
Data from the 1982 breast cancer survey of the American College of Surgeons were used to evaluate factors related to clinical, epidemiologic, and survival differences between black and white patients. Breast cancer in blacks was not discovered as early as in whites. Distribution of pathologic types of tumors were similar for both races with the exception of medullary carcinoma, which was more frequent in blacks than in whites. Estrogen receptor-positive tumors were found significantly less frequently in blacks compared with whites. Survival was better for whites compared with blacks within each axillary nodes group 0, 1 to 3, and 4+. Black women with negative or positive estrogen receptors had lower survival rates than white women of the same receptor status. A regression analysis using Cox's proportional hazards model showed race, clinical stage or axillary nodal status, age at diagnosis, and estrogen receptor status as significant predictors of survival. Significant differences between black and white patients were also observed with respect to the report of family history of breast cancer, age at first pregnancy, number of pregnancies, and age at cessation of menses.
美国外科医生学会1982年乳腺癌调查的数据被用于评估与黑人和白人患者之间临床、流行病学及生存差异相关的因素。黑人乳腺癌的发现不像白人那样早。除髓样癌外，两个种族肿瘤的病理类型分布相似，髓样癌在黑人中比在白人中更常见。与白人相比，黑人中雌激素受体阳性肿瘤的发现频率显著更低。在腋窝淋巴结分组为0、1至3以及4个以上的每组中，白人的生存率都比黑人更好。雌激素受体阴性或阳性的黑人女性的生存率低于相同受体状态的白人女性。使用考克斯比例风险模型进行的回归分析表明，种族、临床分期或腋窝淋巴结状态、诊断时年龄以及雌激素受体状态是生存的显著预测因素。在乳腺癌家族史报告、首次怀孕年龄、怀孕次数以及绝经年龄方面，黑人和白人患者之间也观察到了显著差异。
