Martindale Stacey, Singh Awinder, Wang Hua, Steinberg Ashley, Homsi Amer, Zhang Haidi, Go Alan, Pappas Peter
Department of Surgery, The Brooklyn Hospital Center, 121 Dekalb Avenue, Brooklyn, NY 11201, USA.
Department of Surgery, The Brooklyn Hospital Center, 121 Dekalb Avenue, Brooklyn, NY 11201, USA ; Department of Surgery, Thomas Jefferson University Hospital, Center City Campus, 111 South 11th Street, PA 19107, USA.
ISRN Oncol. 2014 Feb 12;2014:694591. doi: 10.1155/2014/694591. eCollection 2014.
Breast cancer survival has significantly improved over the past two decades. However, the diagnosis of breast cancer is lower and the mortality rate remains higher, in African American women (AA) compared to Caucasian-American women. The purpose of this investigation is to analyze postoperative events that may affect breast cancer survival. This is a retrospective analysis of prospectively collected data from The Brooklyn Hospital Center cancer registry from 1997 to 2010. Of the 1538 patients in the registry, 1226 are AA and 269 are Caucasian. The study was divided into two time periods, 1997-2004 (period A) and 2005-2010 (period B), in order to assess the effect of treatment outcomes on survival. During period A, 5-year survival probabilities of 75.37%, 74.53%, and 78.70% were seen among all patients, AA women and Caucasian women, respectively. These probabilities increased to 87.62%, 87.15% and 89.99% in period B. Improved survival in AA women may be attributed to the use of adjuvant chemotherapy, radiation, and hormonal therapy. Improved survival in Caucasian patients was attributed to the use of radiation therapy, as well as earlier detection resulting in more favorable tumor grades and pathological stages.
在过去二十年中，乳腺癌患者的生存率有了显著提高。然而，与美国白人女性相比，非裔美国女性的乳腺癌诊断率较低，死亡率仍然较高。本研究的目的是分析可能影响乳腺癌生存的术后事件。这是一项对1997年至2010年布鲁克林医院中心癌症登记处前瞻性收集的数据进行的回顾性分析。登记处的1538名患者中，1226名是非裔美国女性，269名是白人女性。为了评估治疗结果对生存的影响，研究分为两个时间段，1997 - 2004年（A期）和2005 - 2010年（B期）。在A期，所有患者、非裔美国女性和白人女性的5年生存率分别为75.37%、74.53%和78.70%。在B期，这些概率分别提高到了87.62%、87.15%和89.99%。非裔美国女性生存率的提高可能归因于辅助化疗、放疗和激素治疗的使用。白人患者生存率的提高归因于放疗的使用，以及早期检测导致更有利的肿瘤分级和病理分期。
