Kushner B H, Vogel R, Hajdu S I, Helson L
Cancer. 1985 Oct 1;56(7):1730-2. doi: 10.1002/1097-0142(19851001)56:7<1730::aid-cncr2820560744>3.0.co;2-i.
Neuroblastoma metastatic to the testes is thought to be an extremely rare event and is therefore not routinely considered in the evaluation of neuroblastoma patients. A review of metastatic sites in a series of neuroblastoma patients, however, revealed 11 cases with testicular involvement. Analysis of these cases suggests that the phenomenon may not be uncommon in a subset of neuroblastoma patients, namely, male patients with infra-diaphragmatic primaries and advanced-stage disease. Because the testes constitute a sanctuary site for tumor cells, occult testicular involvement may play a role in the relapse of patients judged to be in complete remission. Accordingly, it is proposed that in the above group of patients special diagnostic attention should be directed at the scrotal contents and, if testicular involvement is detected, orchiectomy or local irradiation should be considered.
神经母细胞瘤转移至睾丸被认为是极其罕见的事件，因此在神经母细胞瘤患者的评估中通常不会被考虑。然而，对一系列神经母细胞瘤患者的转移部位进行回顾时，发现有11例患者睾丸受累。对这些病例的分析表明，在一部分神经母细胞瘤患者中，即膈下原发性肿瘤且处于晚期疾病的男性患者中，这种现象可能并不罕见。由于睾丸是肿瘤细胞的庇护所，隐匿性睾丸受累可能在被判定为完全缓解的患者复发中起作用。因此，建议对上述患者群体应特别关注阴囊内容物，如果检测到睾丸受累，应考虑进行睾丸切除术或局部放疗。
