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犬咬二氧化碳嗜纤维菌经犬唾液暴露致健康成人严重脓毒症:一例报告

Capnocytophaga canimorsus from Dog Saliva Exposure Causing Severe Sepsis in a Healthy Adult: A Case Report.

作者信息

Stephens Megan A, Silin Nawras, Dakkak Tahani, Sathian Sangamithra, Ghosh Aditya K, Singh Hardeep, Bongu Navneeth

机构信息

Graduate Medical Education Research Department, Northeast Georgia Medical Center, Gainesville, GA, USA.

Department of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GA, USA.

出版信息

Am J Case Rep. 2025 Apr 25;26:e946691. doi: 10.12659/AJCR.946691.

Abstract

BACKGROUND Capnocytophaga canimorsus is a gram-negative bacterium commonly found in the saliva of dogs and cats. It has the ability to evade the human immune system and cause life-threatening infections, particularly in immunocompromised individuals. C. canimorsus infection was first described in 1976, and additional cases have since been reported, with complications varying from mild to severe. This case report highlights the occurrence of a severe C. canimorsus infection in an immunocompetent patient, which rapidly progressed to septic shock and multiorgan failure. CASE REPORT We present the case of a 63-year-old man with no significant past medical history who presented with weakness, fatigue, and confusion. Further investigation revealed a wound on his lower right extremity, which had been licked by his dog. The causative pathogen was identified as C. canimorsus through blood culture and mass spectrometry. The patient experienced septic shock with multiorgan failure, including acute renal failure, liver failure, and coagulopathy. Prompt initiation of empirical broad-spectrum antibiotics prior to identification of the source of infection proved to be beneficial, resulting in clinical and symptomatic improvement for the patient. CONCLUSIONS This case emphasizes the severe complications that can arise from C. canimorsus infection in immunocompetent individuals, underscoring the importance of early recognition and treatment in cases of sepsis, particularly in those with potential dog saliva exposure.

摘要

背景

犬咬二氧化碳嗜纤维菌是一种革兰氏阴性菌,常见于狗和猫的唾液中。它有能力逃避人类免疫系统并引发危及生命的感染,尤其是在免疫功能低下的个体中。犬咬二氧化碳嗜纤维菌感染于1976年首次被描述,此后又有更多病例被报道,其并发症从轻度到重度各不相同。本病例报告强调了一名免疫功能正常的患者发生严重犬咬二氧化碳嗜纤维菌感染的情况,该感染迅速发展为感染性休克和多器官功能衰竭。

病例报告

我们报告一例63岁男性患者,他既往无重大病史,出现虚弱、疲劳和意识模糊症状。进一步检查发现其右下肢有一处伤口,曾被他的狗舔过。通过血培养和质谱分析确定致病病原体为犬咬二氧化碳嗜纤维菌。患者出现感染性休克并伴有多器官功能衰竭,包括急性肾衰竭、肝功能衰竭和凝血功能障碍。在确定感染源之前迅速开始经验性使用广谱抗生素被证明是有益的,患者的临床症状得到改善。

结论

本病例强调了免疫功能正常的个体感染犬咬二氧化碳嗜纤维菌可能引发的严重并发症,突出了在脓毒症病例中早期识别和治疗的重要性,特别是在那些有潜在狗唾液接触史的患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e1e/12035970/0d8e63ddc170/amjcaserep-26-e946691-g001.jpg

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