一种用于新兴正黄病毒属病毒的非感染性假病毒系统。

A noninfectious pseudovirus system for an emerging orthoflavivirus.

作者信息

Shi Yanfan, He Yu, Wang Xiaoli, Wu Zhen, Wang Tao, Wang Mingshu, Jia Renyong, Zhu Dekang, Liu Mafeng, Zhao Xinxin, Yang Qiao, Wu Ying, Zhang Shaqiu, Huang Juan, Ou Xumin, Sun Di, Cheng Anchun, Chen Shun

机构信息

Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.

Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Chengdu, 611130, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education, Sichuan Agricultural University, Chengdu, 611130, China.

出版信息

Virol Sin. 2025 Jun;40(3):495-498. doi: 10.1016/j.virs.2025.04.006. Epub 2025 Apr 23.

DOI:10.1016/j.virs.2025.04.006

PMID:40280237

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12282436/

Abstract

• A -complementation system for Usutu virus (USUV) recapitulates authentic viral replication. • High yield of TMN-ΔNS1 virus was obtained with no recombination into replication competent viruses. • TMN-ΔNS1 can be -complemented by heterologous orthoflavivirus NS1.

摘要

• 乌苏图病毒（USUV）的A-互补系统概括了真实的病毒复制。

• 获得了高产的TMN-ΔNS1病毒，且未重组为具有复制能力的病毒。

• TMN-ΔNS1可由异源黄病毒属病毒NS1进行A-互补。