Black Christopher J, Olano Carolina, Quigley Eamonn M M, Ford Alexander C
Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.
Nat Rev Gastroenterol Hepatol. 2025 Apr 25. doi: 10.1038/s41575-025-01065-9.
Despite an increase in our understanding of the pathophysiology of irritable bowel syndrome (IBS), in the context of abnormal gut-brain axis communication, and advances in both pharmacological and non-pharmacological treatment of the disorder, there remain areas in which there are misconceptions and controversies in the clinical management of IBS. This Perspective aims to highlight some of the most common misconceptions and controversies in IBS management, including those that the scientific literature has resolved, but for which further education of clinicians dealing with patients with IBS might be required to implement the findings from medical research. Areas of remaining contention are also discussed, as are suggestions as to how these issues could be addressed, both by advances in clinical practice and by further research.
尽管我们对肠易激综合征(IBS)的病理生理学有了更多了解,认识到其存在肠道与大脑轴通信异常的情况,并且在该疾病的药物和非药物治疗方面也取得了进展,但在IBS的临床管理中,仍存在一些存在误解和争议的领域。本观点文章旨在强调IBS管理中一些最常见的误解和争议,包括那些科学文献已解决的问题,但可能仍需要对治疗IBS患者的临床医生进行进一步教育,以便他们应用医学研究的结果。还讨论了仍存在争议的领域,以及关于如何通过临床实践的进展和进一步研究来解决这些问题的建议。