Ming Bo-Wen, Liu Wen-Hui, Li Li, Zhang Jin-Lun, Liu Jing, Ma Jia-Jun, Huang Hao-Neng, Zhang Zhou-Bin, Ou Chun-Quan
State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China.
BMC Public Health. 2025 Apr 25;25(1):1551. doi: 10.1186/s12889-025-22437-5.
The high prevalence of hepatitis B weighs heavily on public health in China. In 2009, a catch-up vaccination program for children aged 8-15y was implemented to curb hepatitis B, while the effectiveness of this intervention has not been investigated. We aimed to evaluate the effectiveness of catch-up vaccination on the incidence of hepatitis B in Guangzhou, China.
We obtained individual data of all hepatitis B cases from 2005 to 2019 in Guangzhou from Guangzhou Center for Diseases Control and Prevention. Based on daily reported number of cases, we constructed generalized linear models to estimate the effectiveness of the intervention on the incidence of hepatitis B in each age group from 11 to 25 years. We further estimated the age-standardized effectiveness. Finally, we examined the effectiveness in different subgroups by sex and clinical types of hepatitis B.
A total of 58,204 hepatitis B cases among individuals aged 11-25y were reported in Guangzhou from 2005 to 2019, with an average annual age-standardized incidence of 117.30 cases per 100,000 individuals. The catch-up vaccination contributed to an age-standardized 20.02% (95% confidence interval: 15.97%, 23.87%) decrease in the hepatitis B incidence among individuals aged 11-25y and prevented an annual age-standardized average of 17.40 (95% empirical confidence interval [eCI]: 9.24, 23.78) cases per 100,000 individuals from hepatitis B during the study period. The intervention could better protect males (excess incidence rate [EIR]: -21.82 [95% eCI: -30.51, -10.15] cases per 100,000 individuals), and prevent chronic cases (EIR: -24.27 [95% eCI: -30.62, -16.09] cases per 100,000 individuals).
The massive catch-up vaccination against hepatitis B among children plays an important role in alleviating the burden of hepatitis B.
乙肝的高流行率给中国的公共卫生带来了沉重负担。2009年，中国实施了针对8至15岁儿童的补种疫苗计划以控制乙肝，但该干预措施的效果尚未得到研究。我们旨在评估中国广州补种疫苗对乙肝发病率的效果。
我们从广州市疾病预防控制中心获取了2005年至2019年广州所有乙肝病例的个体数据。基于每日报告的病例数，我们构建了广义线性模型，以估计该干预措施对11至25岁各年龄组乙肝发病率的效果。我们进一步估计了年龄标准化效果。最后，我们按性别和乙肝临床类型检查了不同亚组中的效果。
2005年至2019年，广州共报告了11至25岁个体中的58204例乙肝病例，年龄标准化年发病率平均为每10万人117.30例。补种疫苗使11至25岁个体的乙肝发病率年龄标准化降低了20.02%（95%置信区间：15.97%，23.87%），并在研究期间每10万人每年预防了年龄标准化平均17.40例（95%经验置信区间[eCI]：9.24，23.78）乙肝病例。该干预措施对男性的保护效果更好（超额发病率[EIR]：每10万人-21.82例[95% eCI：-30.51，-10.15]），并预防了慢性病例（EIR：每10万人-24.27例[95% eCI：-30.62，-16.09]）。
大规模的儿童乙肝补种疫苗在减轻乙肝负担方面发挥了重要作用。
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