Spînu Ștefan, Sur Daniel, Creciun Veronica, Moșoiu Daniela, Ciurescu Daniel
Medlife Oncology Hospital, 500052 Brașov, Romania.
Medical Oncology Department, Oncology Institute "Prof. Dr. Ion Chiricuţă", 400015 Cluj-Napoca, Romania.
Healthcare (Basel). 2025 Apr 18;13(8):931. doi: 10.3390/healthcare13080931.
The rationale of the present study is to measure the impact of chemotherapy on the pain caused by the disease. The present study was based on the completion of two standardized questionnaires for the assessment of physical symptoms (Brief Pain Inventory-BPI-and the revised Edmonton Symptom Assessment System-ESASr) in three different moments. The research was conducted at the Oncology Institute "Prof. Dr. Ion Chiricuță" Cluj-Napoca between 2022 and 2023. 24 patients were included in the study, and they received different cytostatic treatment regimens, adapted to the underlying pathology. We analyzed the distribution of all symptoms from the ESASr and the total score. In terms of the general situation, if we exclude pain, there is never a difference between Time 2 and 3. Furthermore, in all cases where there is a statistically significant effect, there is a difference between Time 1 and 3. We also analyzed the distribution of activities with which pain interacts in BPI. Regarding the general situation, three patterns of influence of pain on the examined parameters are found: for general activity, mood, ability to work, and sleep, there are significant differences between moments 1 and 2 and 1 and 3, without significant differences between moments 2 and 3. The second pattern identified refers to the lack of effect of pain on the ability to walk and on the relationship with other people. The peculiarity is represented by the influence on the enjoyment of life that was significantly improved only from Time 1 to 3. The present study demonstrated a considerable effect of cytostatic treatment on the management of cancer-related pain, as shown across different evaluations.
本研究的基本原理是测量化疗对疾病所致疼痛的影响。本研究基于在三个不同时间点完成的两份用于评估身体症状的标准化问卷（简明疼痛量表 - BPI - 和修订版埃德蒙顿症状评估系统 - ESASr）。该研究于2022年至2023年在克卢日 - 纳波卡的“伊翁·基里库ță教授博士”肿瘤研究所进行。24名患者被纳入研究，他们接受了根据基础病理情况调整的不同细胞毒性治疗方案。我们分析了ESASr中所有症状的分布情况以及总分。就总体情况而言，如果排除疼痛，时间2和时间3之间从未有差异。此外，在所有具有统计学显著效应的情况下，时间1和时间3之间存在差异。我们还分析了BPI中疼痛与之相互作用的活动的分布情况。就总体情况而言，发现疼痛对所检查参数有三种影响模式：对于一般活动、情绪、工作能力和睡眠，时间1与时间2以及时间1与时间3之间存在显著差异，时间2与时间3之间无显著差异。确定的第二种模式是疼痛对行走能力和与他人关系没有影响。其独特之处在于对生活乐趣的影响，仅从时间1到时间3有显著改善。本研究表明，如不同评估所示，细胞毒性治疗对癌症相关疼痛的管理有相当大的效果。
