Estes N C, Morphis J G, Hornback N B, Jewell W R
Am J Surg. 1986 Dec;152(6):597-601. doi: 10.1016/0002-9610(86)90433-2.
For the majority of patients with unresectable recurrence of rectal cancer, persistent pain is the most distressing problem. This brief study describes a method to control pain in 10 patients with unresectable rectal cancer confined to the pelvis after standard therapy failed. All of the patients had percutaneous placement of infusion catheters in both internal iliac arteries. A continuous intraarterial infusion of 800 mg/m2 of 5-fluorouracil per day was given for 7 days and 10 mg/m2 of mitomycin C was administered as a bolus injection on the seventh day only. Four patients also received whole body hyperthermia by way of a Erbotherm 434 mHz microwave generator on the second and fifth days of infusion. Relief of pain occurred in three of the six patients who received intraarterial chemotherapy only. All four patients who also received hyperthermia achieved prolonged pain relief when it was added. We have concluded that intraarterial chemotherapy may be beneficial in patients with uncontrolled pelvic pain due to recurrent rectal cancer. The addition of hyperthermia may augment the benefit.
对于大多数无法切除的直肠癌复发患者而言，持续性疼痛是最令人苦恼的问题。这项简短的研究描述了一种在标准治疗失败后，用于控制10例局限于盆腔的无法切除直肠癌患者疼痛的方法。所有患者均经皮在双侧髂内动脉置入输液导管。每天持续动脉内输注800mg/m²的5-氟尿嘧啶，共7天，仅在第7天推注10mg/m²的丝裂霉素C。4例患者在输注的第2天和第5天还通过Erbotherm 434 mHz微波发生器进行了全身热疗。仅接受动脉内化疗的6例患者中有3例疼痛缓解。另外接受热疗的所有4例患者在加用热疗后疼痛缓解期延长。我们得出结论，动脉内化疗可能对因复发性直肠癌导致盆腔疼痛无法控制的患者有益。加用热疗可能会增加益处。
