Uher Ivan, Bergendyová Eva, Poráčová Janka, Bernasovská Jarmila
Institute of Physical Education and Sport, Pavol Jozef Šafárik University, 04180 Kosice, Slovakia.
Clinic of Radiation and Clinical Oncology, FNsP J.A. Reiman, Hollého 14, 08001 Presov, Slovakia.
Healthcare (Basel). 2025 Apr 19;13(8):944. doi: 10.3390/healthcare13080944.
The human papillomavirus type 16 (HPV 16) is a high-risk human papillomavirus strain commonly associated with oropharyngeal cancers, including lymph node involvement. The treatment for HPV 16-related tonsil cancer, commonly involving surgery, radiation, and chemotherapy, presents significant challenges. Complications such as oral mucositis, xerostomia, dysphagia, dysgeusia, hypogeusia, impaired gustatory function, and significant weight loss frequently arise, leading to reduced nutritional intake, impaired healing, and recovery progression. These challenges underscore the need for supportive interventions to enhance rehabilitation and the post-recovery period, improve treatment tolerance, and maintain quality of life. This single-subject study examines a 67-year-old male patient diagnosed with a T1N3b (small primary tumor with advanced lump node involvement) associated with HPV 16 positivity, indicating a virus-associated oncogenesis. The patient underwent radiation therapy and chemotherapy, leading to treatment-associated side effects. After having dietary drinks for daily nourishment, the patient routinely incorporated oral bio extra virgin olive oil (BEVOO) to cope with indicated challenges. Body composition and metabolic parameters showed treatment-induced declines, followed by substantial but not complete recovery during follow-up examination. Visual Analog Scale (VAS) scores reflected gradual improvements in dysphagia, xerostomia, mucositis, and subtle but ongoing enhancement of the dysgeusia, gustatory perception, and oral palatability. The BEVOO supplementation and mindfulness were associated with positive recovery trends. Additional variables could have impacted the outcomes, preceding and throughout treatment, including the patient's cognitive and somatic health, environmental conditions, dietary habits, individual attitudes toward recovery, physical activity, and patient way of life. These results emphasize the need for additional research employing a comprehensive, multi-factorial framework that accounts for the complex interplay of physiological, psycho-social, and environmental contributors. More extensive, more diverse studies are essential to confirm these observations and substantiate the role of BEVOO as a supportive intervention in cancer recovery.
16型人乳头瘤病毒（HPV 16）是一种高危型人乳头瘤病毒毒株，通常与口咽癌有关，包括淋巴结受累。HPV 16相关扁桃体癌的治疗通常包括手术、放疗和化疗，面临重大挑战。口腔黏膜炎、口干、吞咽困难、味觉障碍、味觉减退、味觉功能受损和体重显著减轻等并发症经常出现，导致营养摄入减少、愈合受损和恢复进程受阻。这些挑战凸显了采取支持性干预措施以加强康复和康复后期、提高治疗耐受性以及维持生活质量的必要性。这项单病例研究考察了一名67岁男性患者，他被诊断为T1N3b（原发性小肿瘤伴晚期淋巴结受累）且HPV 16呈阳性，提示病毒相关的肿瘤发生。该患者接受了放疗和化疗，导致出现治疗相关副作用。在饮用日常营养饮品后，患者常规摄入口服生物特级初榨橄榄油（BEVOO）以应对上述挑战。身体成分和代谢参数显示出治疗导致的下降，随后在随访检查期间有显著但未完全恢复的情况。视觉模拟量表（VAS）评分反映出吞咽困难、口干、黏膜炎逐渐改善，味觉障碍、味觉感知和口腔适口性有细微但持续的改善。补充BEVOO和正念与积极的恢复趋势相关。在治疗之前及整个治疗过程中，其他变量可能影响了结果，包括患者的认知和躯体健康、环境条件、饮食习惯、对康复的个人态度、身体活动以及患者的生活方式。这些结果强调了需要采用综合、多因素框架进行更多研究，该框架要考虑到生理、心理社会和环境因素的复杂相互作用。更广泛、更多样化的研究对于证实这些观察结果并证实BEVOO作为癌症康复支持性干预措施的作用至关重要。
