Tastemur Mercan, Ozdemir Cagla, Olcucuoğlu Esin, Besler Muhammed Said, Tekdemir Halil, Arik Gunes, Silay Kamile
Department of Geriatrics Medicine, Ankara Bilkent City Hospital, Ministry of Health, Ankara 06800, Turkey.
Evliya Çelebi Training and Research Hospital, Kütahya Health Sciences University, Kütahya 43020, Turkey.
Medicina (Kaunas). 2025 Apr 12;61(4):711. doi: 10.3390/medicina61040711.
: With physiological aging, the pancreas is expected to decrease in size as in every organ. The objective of this study was to examine the correlation between pancreas volume (PV), nutritional status, and glycolyzed hemoglobin A1c (HbA1c) in elderly patients with and without type 2 diabetes mellitus (DM). : Between July 2020 and April 2022, 109 patients aged ≥ 65 years who applied to geriatrics clinics and outpatient clinics were included in the study. PV was measured from available abdominal contrast-enhanced computed tomography (CT) scans. Patients were divided into two groups according to the presence of DM. The relationship between PV; biochemical parameters, especially HbA1c; and Mini Nutritional Assessment Short Form (MNAsf) score was analyzed between groups. < 0.05 was considered statistically significant. The mean age of all participants was M: 77.40, with SD: 7.32. A total of 54.1% of the participants were female, and 55 had DM. There were no significant differences in age and gender between those with and without DM. Glucose ( < 0.001), HbA1C ( < 0.001), and triglycerides ( < 0.001) were significantly higher, and HDL ( < 0.001) was significantly lower in patients with DM. PV was also significantly lower in those with DM ( = 0.028). A correlation analysis revealed significant positive correlations between PV, the MNAsf score (rho (109)) = 0.413, = 0.003), and lipase (rho (109)) = 0.297, = 0.002). PV, which is expected to decrease with age, was found to be lower in patients with DM in our study in which we evaluated elderly patients with and without DM. We also found that PV was associated with malnutrition. Our study highlights the importance of determining the clinical effects of pancreatic volume in the geriatric population where organ atrophy is expected. Therefore, we believe that more comprehensive studies are needed to clarify the clinical implications of pancreatic volume on our diagnostic and therapeutic decisions.
随着生理衰老，胰腺预计会像其他器官一样体积减小。本研究的目的是检查老年2型糖尿病（DM）患者和非2型糖尿病患者的胰腺体积（PV）、营养状况和糖化血红蛋白A1c（HbA1c）之间的相关性。：在2020年7月至2022年4月期间，109名年龄≥65岁且到老年病诊所和门诊就诊的患者被纳入研究。从可用的腹部增强计算机断层扫描（CT）中测量PV。根据是否患有DM将患者分为两组。分析了两组之间PV、生化参数（尤其是HbA1c）和简易营养评估简表（MNAsf）评分之间的关系。P<0.05被认为具有统计学意义。所有参与者的平均年龄为M：77.40，标准差为SD：7.32。共有54.1%的参与者为女性，55人患有DM。患有DM和未患有DM的患者在年龄和性别上没有显著差异。DM患者的血糖（P<0.001）、HbA1C（P<0.001）和甘油三酯（P<0.001）显著更高，高密度脂蛋白（HDL，P<0.001）显著更低。DM患者的PV也显著更低（P=0.028）。相关性分析显示PV与MNAsf评分（rho（109）=0.413，P=0.003）和脂肪酶（rho（109）=0.297，P=0.002）之间存在显著正相关。在我们评估老年DM患者和非DM患者的研究中，预计随年龄增长而减小的PV在DM患者中更低。我们还发现PV与营养不良有关。我们的研究强调了在预期器官萎缩的老年人群中确定胰腺体积临床影响的重要性。因此，我们认为需要更全面的研究来阐明胰腺体积对我们诊断和治疗决策的临床意义。
