Demianenko Volodymyr, Schlömicher Markus, Grossmann Marius, Belmenai Ahmed, Dörge Hilmar, Sellin Christian
Department of Cardiothoracic Surgery, Heart-Thorax Center, Klinikum Fulda, University Medicine Marburg, Campus Fulda, Pacelliallee 4, 36043 Fulda, Germany.
J Clin Med. 2025 Apr 8;14(8):2545. doi: 10.3390/jcm14082545.
Severe obesity significantly increases the risk of complications following full sternotomy in coronary artery bypass grafting (CABG). However, these patients are frequently excluded from less invasive, sternum-sparing surgical alternatives. This study aimed to assess the safety and practicality of a newly developed technique-Total Coronary Revascularization via left Anterior miniThoracotomy (TCRAT)-that avoids sternotomy in patients with severe obesity requiring multivessel CABG. From November 2019 to May 2024, a total of 502 non-emergency patients with multivessel coronary artery disease underwent CABG through a left anterior minithoracotomy using cardiopulmonary bypass (CPB) and cardioplegic arrest. Of these, 43 patients with a body mass index (BMI) exceeding 35.0 kg/m were classified as severely obese and included for subgroup analysis. Their outcomes were compared to those of the remaining 459 patients with BMI below 35.0 kg/m. Key intraoperative variables-such as total operative time, CPB duration, aortic cross-clamp time, and graft strategy-were evaluated. Postoperative outcomes, such as the incidence of major adverse cardiac and cerebrovascular events, minor complications, and length of stay in ICU and hospital, were also analyzed. : Severely obese patients exhibited a longer total operation time (353.5 ± 83.6 min vs. 320.4 ± 73.4 min, < 0.05). In contrast, no statistical differences were observed in aortic cross-clamp time (97.9 ± 27.6 min vs. 95.6 ± 33.0 min; = 0.307) or CPB time (163.3 ± 35.0 min vs. 155.0 ± 42.9 min; = 0.078). Both groups received a similar number of distal anastomoses (3.1 ± 0.7 vs. 3.0 ± 0.8; = 0.194), and the frequency of total arterial revascularization was comparable (34.9% vs. 40.0%; = 0.268). There were no differences between the groups in major complications, including hospital mortality (2.3% vs. 1.1%, = 0.227), stroke (0.0% vs. 0.6% = 0.300), or need for re-revascularization (0.0% vs. 1.1%, = 0.248). Similarly, minor complications, such as wound healing issues (2.3% vs. 1.1%, = 0.233) and revisions for bleeding (4.6% vs. 7.2%, = 0.276), were comparable between groups. ICU stay (2.7 ± 4.5 days vs. 2.2 ± 4.0 days; = 0.225) and total hospital stay (12.3 ± 9.6 days vs. 10.8 ± 8.6 days; = 0.142) showed no meaningful differences. : TCRAT can be performed safely and effectively in severely obese patients, providing a feasible minimally invasive option for complete coronary revascularization in cases of multivessel disease. This approach eliminates the complications associated with sternotomy, making it a valuable surgical alternative for this high-risk patient group.
严重肥胖显著增加冠状动脉旁路移植术(CABG)正中开胸术后并发症的风险。然而,这些患者常被排除在创伤较小、不劈开胸骨的手术替代方案之外。本研究旨在评估一种新开发的技术——经左前小切口全冠状动脉血运重建术(TCRAT)——在需要多支血管CABG的严重肥胖患者中避免开胸的安全性和实用性。2019年11月至2024年5月,共有502例非急诊多支血管冠状动脉疾病患者通过左前小切口在体外循环(CPB)和心脏停搏下进行了CABG。其中,43例体重指数(BMI)超过35.0kg/m²的患者被归类为严重肥胖,并纳入亚组分析。将他们的结果与其余459例BMI低于35.0kg/m²的患者进行比较。评估了关键的术中变量,如总手术时间、CPB持续时间、主动脉阻断时间和移植策略。还分析了术后结果,如主要不良心脑血管事件的发生率、轻微并发症以及在ICU和医院的住院时间。严重肥胖患者的总手术时间更长(353.5±83.6分钟对320.4±73.4分钟,P<0.05)。相比之下,主动脉阻断时间(97.9±27.6分钟对95.6±33.0分钟;P=0.307)或CPB时间(163.3±35.0分钟对155.0±42.9分钟;P=0.078)没有统计学差异。两组接受的远端吻合数量相似(3.1±0.7对3.0±0.8;P=0.194),全动脉血运重建的频率相当(34.9%对40.0%;P=0.268)。两组在主要并发症方面没有差异,包括医院死亡率(2.3%对1.1%,P=0.227)、中风(0.0%对0.6%,P=0.300)或再次血运重建的需求(0.0%对1.