Sánchez-Sellero Inés, Soto-Varela Andrés
Division of Toxicology, Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Pediatrics, School of Medicine, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Forensic Toxicology Service, Forensic Sciences Institute, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
J Clin Med. 2025 Apr 8;14(8):2555. doi: 10.3390/jcm14082555.
: The association between vestibular symptoms and psychological distress has been previously studied, mainly with the use of questionnaires. The purpose of this study is to compare the consumption of psychotropic drugs between a group of patients with vertigo and a control group. : A prospective cross-sectional, observational, case-control study was carried out, including 506 patients (232 with Ménière's disease, 79 with vestibular migraine, 34 with vestibular neuritis, and 161 with benign paroxysmal positional vertigo). In total, 253 participants were included in the control group. Both groups were comparable regarding age, sex, and history of previous psychiatric diseases. : The percentage of patients with vertigo who consumed psychotropic drugs (41.3%) was higher than the percentage of the control group who did so (26.9%) (Fisher's exact test, < 0.0001; OR = 1.914, CI95% (1.377; 2.662)). The mean number of psychotropic drugs consumed was also higher (Mann-Whitney test, = 0.0003) in cases (0.68 ± 0.959) than in controls (0.47 ± 0.889). This higher consumption in the group of patients with vertigo was found for all pharmacological groups studied, being especially relevant regarding "anxiolytics and hypnotics and sedatives" and "antidepressants". No statistically significant differences in the consumption of psychotropic drugs between types of vestibular disorders were observed. The longer the symptoms were present, the higher the prevalence of psychotropic drug use was observed. : A relationship between vertigo and consumption of psychotropic drugs was found. Recording the consumption of these drugs is proposed as an objective method to better understand the psychological distress that patients with vertigo may suffer from.
前庭症状与心理困扰之间的关联此前已有研究，主要采用问卷调查的方式。本研究的目的是比较一组眩晕患者与对照组之间精神药物的使用情况。
开展了一项前瞻性横断面观察性病例对照研究，纳入506例患者（232例梅尼埃病、79例前庭性偏头痛、34例前庭神经炎和161例良性阵发性位置性眩晕）。对照组共纳入253名参与者。两组在年龄、性别和既往精神疾病史方面具有可比性。
眩晕患者中使用精神药物的比例（41.3%）高于对照组（26.9%）（Fisher精确检验，<0.0001；OR = 1.914，95%CI（1.377；2.662））。病例组（0.68±0.959）使用精神药物的平均数量也高于对照组（0.47±0.889）（Mann-Whitney检验，= 0.0003）。在所有研究的药物类别中，眩晕患者组的药物使用量均较高，尤其是“抗焦虑药、催眠药和镇静药”以及“抗抑郁药”。在前庭疾病类型之间，精神药物的使用量未观察到统计学上的显著差异。症状出现的时间越长，精神药物使用的患病率越高。
发现眩晕与精神药物的使用之间存在关联。建议记录这些药物的使用情况，作为一种客观方法，以更好地了解眩晕患者可能遭受的心理困扰。
