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炎症性肠病患者妊娠前、妊娠期间及妊娠后的多学科护理路径的制定

The Development of a Multidisciplinary Care Pathway for Patients with Inflammatory Bowel Disease Before, During and After Pregnancy.

作者信息

De Dycker Els, Lenie Sien, Ceulemans Michael, Geens Patricia, Lambrechts Tessy, Loddewijkx Elien, Paps Ariane, Degry Justien, D'Hondt Caroline, Matthijs Annelies, Vermeire Séverine, Sabino João, Verstockt Bram, Lannoo Lore, Van Calsteren Kristel, Ferrante Marc

机构信息

Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, 3000 Leuven, Belgium.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.

出版信息

J Clin Med. 2025 Apr 11;14(8):2644. doi: 10.3390/jcm14082644.

DOI:10.3390/jcm14082644
PMID:40283474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12027973/
Abstract

: Recent advancements have significantly enhanced our understanding of the interplay between inflammatory bowel disease (IBD) and reproductive health. While international organizations provide guidelines for best practices, translating them into actionable strategies is crucial. This study aimed to develop a comprehensive care pathway to enhance preconception counselling and support for patients with IBD in the perinatal period, ensuring they receive optimal expert care. : We used the 7-phase model for the development of the care pathway. : The resulting care pathway, structured as a time-task matrix, outlines the required actions at preconception, during pregnancy, and in the postpartum period for women with IBD. The pathway provides a structured and multidisciplinary approach that addresses the unique needs of patients with IBD of childbearing age. It emphasizes holistic and personalized support throughout the preconception, pregnancy, and postpartum period. : The development of this care pathway represents a significant advancement in the perinatal management of IBD. By offering multidisciplinary and individualized care, optimal maternal and infant outcomes are pursued, while establishing a new global standard for reproductive health and perinatal management.

摘要

近期的进展显著增进了我们对炎症性肠病(IBD)与生殖健康之间相互作用的理解。虽然国际组织提供了最佳实践指南,但将其转化为可操作的策略至关重要。本研究旨在制定一条全面的护理路径,以加强围产期IBD患者的孕前咨询和支持,确保他们获得最佳的专家护理。我们使用了7阶段模型来制定护理路径。由此产生的护理路径以时间 - 任务矩阵的形式构建,概述了IBD女性在孕前、孕期和产后所需采取的行动。该路径提供了一种结构化的多学科方法,满足了育龄IBD患者的独特需求。它强调在孕前、孕期和产后期间提供全面和个性化的支持。这条护理路径的制定代表了IBD围产期管理的重大进展。通过提供多学科和个性化护理,追求最佳的母婴结局,同时建立生殖健康和围产期管理的新全球标准。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa0/12027973/4a2a6f9e9a03/jcm-14-02644-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa0/12027973/38c585478461/jcm-14-02644-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa0/12027973/4a2a6f9e9a03/jcm-14-02644-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa0/12027973/38c585478461/jcm-14-02644-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa0/12027973/4a2a6f9e9a03/jcm-14-02644-g002.jpg

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本文引用的文献

1
Active Inflammatory Bowel Disease on Intestinal Ultrasound During Pregnancy Is Associated With an Increased Risk of Adverse Pregnancy and Neonatal Outcomes Independent of Clinical and Biochemical Disease Activity.孕期肠道超声检查显示的活动性炎症性肠病与不良妊娠和新生儿结局风险增加相关,且独立于临床和生化疾病活动情况。
Gastroenterology. 2025 Sep;169(4):647-662. doi: 10.1053/j.gastro.2025.03.016. Epub 2025 Mar 25.
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The Role of Intestinal Ultrasound During Pregnancy in Patients With Inflammatory Bowel Disease.肠道超声在炎症性肠病患者孕期的作用
Am J Gastroenterol. 2023 Nov 1;118(11):2096-2097. doi: 10.14309/ajg.0000000000002402.
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Inflammatory bowel disease in pregnancy and breastfeeding.
妊娠和哺乳期炎症性肠病。
Nat Rev Gastroenterol Hepatol. 2023 Aug;20(8):504-523. doi: 10.1038/s41575-023-00758-3. Epub 2023 Mar 31.
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European Crohn's and Colitis Guidelines on Sexuality, Fertility, Pregnancy, and Lactation.欧洲克罗恩病和结肠炎学会关于性、生育、妊娠及哺乳的指南
J Crohns Colitis. 2023 Jan 27;17(1):1-27. doi: 10.1093/ecco-jcc/jjac115.
5
Intestinal Ultrasound to Evaluate Treatment Response During Pregnancy in Patients With Inflammatory Bowel Disease.肠超声评估妊娠中炎症性肠病患者的治疗反应。
Inflamm Bowel Dis. 2022 Jul 1;28(7):1045-1052. doi: 10.1093/ibd/izab216.
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The Influence of Disease Activity on Pregnancy Outcomes in Women With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.炎症性肠病女性疾病活动度对妊娠结局的影响:系统评价和荟萃分析。
J Crohns Colitis. 2021 May 4;15(5):719-732. doi: 10.1093/ecco-jcc/jjaa225.
7
Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti-TNF or conventional therapy: results of the European CONCEIVE study.接受维得利珠单抗、抗 TNF 或常规治疗的炎症性肠病患者的妊娠结局:欧洲 CONCEIVE 研究结果。
Aliment Pharmacol Ther. 2020 Jan;51(1):129-138. doi: 10.1111/apt.15539. Epub 2019 Nov 6.
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Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group.妊娠期炎症性肠病临床护理路径:美国胃肠病学会IBD育儿项目工作组报告
Gastroenterology. 2019 Apr;156(5):1508-1524. doi: 10.1053/j.gastro.2018.12.022. Epub 2019 Jan 16.
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SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence): revised publication guidelines from a detailed consensus process.SQUIRE 2.0(卓越质量改进报告标准):通过详细的共识过程制定的修订版出版指南。
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