Moulton A L, Brenner J I, Ringel R, Nordenberg A, Berman M A, Ali S, Burns J
Circulation. 1985 Sep;72(3 Pt 2):II35-44.
Between July 1979 and October 1984, 61 systemic-pulmonary arterial shunts were created in 45 patients. Clinical and angiographic results with 23 classic Blalock-Taussig shunts (BTSs) and 35 modified Blalock-Taussig shunts (MBTSs) with polytetrafluoroethylene grafts between the subclavian and pulmonary arteries were compared. Forty-three of the patients studied were infants: 28 were less than 1 month old, and 19 were less than 1 week old. Weights were 1.1 to 19 kg (mean 2.9 kg). Diagnoses were complex tetralogy of Fallot (18 patients), transposition of the great arteries with small left ventricle or left ventricular outflow tract obstruction (six patients) pulmonary atresia (seven patients) with intact ventricular septum (three) and ventricular septal defect (four), tricuspid atresia (four patients), univentricular heart (six patients), atrioventricular septal defect (canal) with pulmonary stenosis (three patients), and double-outlet right ventricle (one patient). Comparison groups were concurrent and were equivalent for age, weight, and complexity of anomaly. Patients were removed from the study population at the time of subsequent open heart surgery or at death. All patients were followed for a minimum of 6 months and for up to 5 1/2 years (BTS 1 1/2 to 5 1/2 years, mean 33 months; MBTS 6 months to 3 years, mean 20 months). There were no intraoperative deaths in either group. Among the 23 BTSs, three failed at 1, 3, and 19 days, resulting in two deaths (17%). One premature infant died despite a second shunt, one died during attempted intracardiac repair at 13 days of age, and the other was well after revision of the shunt. Eight patients underwent subsequent intracardiac repair 1 to 5 years (mean 34 months) after the initial procedure. Another four patients died from complex intracardiac anomalies with patent shunts. Three patients are alive 2 to 4 years after receiving shunts and have not undergone subsequent surgery. Late postoperative angiograms demonstrate a disturbing incidence (21%) of stenosis and right pulmonary arterial deformity despite satisfactory immediate postoperative studies and good clinical function. Eight patients required a second shunt, two for anatomic discontinuity of the pulmonary arteries and six because of inadequate blood flow through the first shunt. Among the 35 patients receiving the MBTS, two required early revision (technical error and ductal tissue at the anastomosis). There were no shunt-related deaths, but three (6%) occurred within 30 days of operation from left ventricular infarct, cerebral hemorrhage, sepsis, and severe aortic stenosis with arrhythmias.(ABSTRACT TRUNCATED AT 400 WORDS)
1979年7月至1984年10月期间,45例患者接受了61次体肺分流术。比较了23例经典Blalock-Taussig分流术(BTS)和35例采用聚四氟乙烯移植物在锁骨下动脉与肺动脉之间进行的改良Blalock-Taussig分流术(MBTS)的临床及血管造影结果。研究的43例患者为婴儿:28例小于1个月,19例小于1周。体重为1.1至19千克(平均2.9千克)。诊断包括复杂法洛四联症(18例患者)、大动脉转位合并小左心室或左心室流出道梗阻(6例患者)、室间隔完整的肺动脉闭锁(7例患者)(其中3例合并室间隔缺损、4例合并室间隔缺损)、三尖瓣闭锁(4例患者)、单心室(6例患者)、房室间隔缺损(心内膜垫缺损)合并肺动脉狭窄(3例患者)以及右心室双出口(1例患者)。比较组为同期患者,在年龄、体重和畸形复杂性方面相当。患者在随后的心脏直视手术时或死亡时被排除出研究人群。所有患者至少随访6个月,最长随访5.5年(BTS为1.5至5.5年,平均33个月;MBTS为6个月至3年,平均20个月)。两组均无术中死亡。在23例BTS中,3例分别在术后1天、3天和19天分流失败,导致2例死亡(17%)。1例早产儿尽管进行了第二次分流仍死亡,1例在13日龄进行心脏内修复尝试时死亡,另1例在分流修正后情况良好。8例患者在初次手术后1至5年(平均34个月)接受了后续心脏内修复。另外4例患者因复杂心脏内畸形且分流通畅而死亡。3例患者在接受分流术后2至4年存活,未进行后续手术。术后晚期血管造影显示,尽管术后即刻检查结果满意且临床功能良好,但仍有令人不安的狭窄发生率(21%)及右肺动脉畸形。8例患者需要进行第二次分流,2例因肺动脉解剖连续性中断,6例因通过初次分流的血流量不足。在接受MBTS的35例患者中,2例需要早期修正(技术失误及吻合口处有导管组织)。无分流相关死亡,但3例(6%)在术后30天内死于左心室梗死、脑出血、败血症以及严重主动脉狭窄合并心律失常。(摘要截取自400字)