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免疫检查点抑制剂相关性心肌炎的多模态成像

Multimodal Imaging of Immune Checkpoint Inhibitor Myocarditis.

作者信息

Patel Shreyans, Dave Kartikeya, Garcia Mario J, Gongora Carlos A, Travin Mark I, Zhang Lili

机构信息

Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.

Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.

出版信息

J Clin Med. 2025 Apr 21;14(8):2850. doi: 10.3390/jcm14082850.

Abstract

Immune checkpoint inhibitors (ICIs) have dramatically changed the landscape of cancer treatment and are increasingly used either as monotherapy or in combination with other ICIs, chemotherapy, and molecularly targeted agents. ICI myocarditis is a rare but potentially fatal irAE associated with the use of ICI characterized by T-cell mediated cardiomyocyte death. Diagnosing ICI myocarditis can be intricate as its atypical presentations. Multimodal imaging plays a crucial role in the diagnosis and risk stratification of ICI myocarditis. Current management strategies for ICI myocarditis include corticosteroids and immunosuppressants. Multidisciplinary collaboration is vital in these cases-combining oncology expertise with cardiology insights.

摘要

免疫检查点抑制剂(ICIs)极大地改变了癌症治疗的格局,越来越多地被用作单一疗法,或与其他ICIs、化疗和分子靶向药物联合使用。ICI心肌炎是一种罕见但可能致命的免疫相关不良反应,与ICI的使用有关,其特征是T细胞介导的心肌细胞死亡。由于ICI心肌炎的表现不典型,其诊断可能很复杂。多模态成像在ICI心肌炎的诊断和风险分层中起着关键作用。目前ICI心肌炎的治疗策略包括使用皮质类固醇和免疫抑制剂。在这些病例中,多学科合作至关重要——将肿瘤学专业知识与心脏病学见解相结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489d/12028134/68aec5db8cdf/jcm-14-02850-g001.jpg

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