Menezes Carlos Felipe Sousa, Lage Lucas Meneses, Santos Luís Gustavo Souza, Nascimento Gilvan Cortês, Magalhães Marcelo, Facundo Alexandre, Silva Dayse Aparecida, Porto Luís Cristóvão, Gomes Marília Brito, Faria Manuel Dos Santos, Azulay Rossana Sousa, Rodrigues Vandilson
School of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil.
Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil.
Int J Environ Res Public Health. 2025 Mar 27;22(4):512. doi: 10.3390/ijerph22040512.
This study aimed to investigate the relationship between Class II human leukocyte antigen (HLA) alleles (DRB1, DQA1, and DQB1) and the severity and extent of periodontitis in patients with Type 1 diabetes (T1D). A cross-sectional study was conducted with 49 patients with T1D. Demographic data and diabetes history were collected. A clinical examination was performed to assess periodontal variables. The patients were categorized by the periodontitis severity and the extent of periodontitis. Peripheral blood samples were analyzed to identify the percentage of autosomal ancestry (Native American, European, and African) and the HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles. The DRB103 and DRB115 haplogroups were significantly associated with an increased risk of generalized periodontitis (OR = 19.8, 95% CI = 1.14-346, = 0.003; OR = 41.2, 95% CI = 1.85-917, < 0.001) and severe periodontitis (OR = 7.7, 95% CI = 1.68-35.5, = 0.003; OR = 21.2, 95% CI = 0.97-461, = 0.005). No associations were observed between the HLA-DQA1 and HLA-DQB1 alleles and periodontitis. These findings suggest that patients with T1D from a highly mixed Brazilian population carrying the DRB103 and DRB115 haplogroups are at higher risk for developing more severe and generalized forms of periodontitis.
本研究旨在调查Ⅱ类人类白细胞抗原（HLA）等位基因（DRB1、DQA1和DQB1）与1型糖尿病（T1D）患者牙周炎的严重程度和范围之间的关系。对49例T1D患者进行了一项横断面研究。收集了人口统计学数据和糖尿病病史。进行了临床检查以评估牙周变量。根据牙周炎的严重程度和范围对患者进行分类。分析外周血样本以确定常染色体血统（美洲原住民、欧洲人和非洲人）的百分比以及HLA-DRB1*、HLA-DQA1和HLA-DQB1等位基因。DRB103和DRB115单倍型与广泛性牙周炎风险增加显著相关（OR = 19.8，95%CI = 1.14 - 346，P = 0.003；OR = 41.2，95%CI = 1.85 - 917，P < 0.001）和重度牙周炎（OR = 7.7，95%CI = 1.68 - 35.5，P = 0.003；OR = 21.2，95%CI = 0.97 - 461，P = 0.005）。未观察到HLA-DQA1和HLA-DQB1等位基因与牙周炎之间存在关联。这些发现表明，来自高度混合的巴西人群且携带DRB103和DRB115单倍型的T1D患者发生更严重和广泛性牙周炎的风险更高。
