Brown Jerry M, Baran Jessica V, Lamos Luke, Beacker Jesse, Florio Jared, Oliveros Lea V, Fabbrini Abigail L, Farrar Andrew A, Wilsey Michael J
Office of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USA.
Office of Medical Education, Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA.
Nutrients. 2025 Apr 9;17(8):1302. doi: 10.3390/nu17081302.
Infant functional disorders, including colic, irritability, and sleep disturbances, often overlap with symptoms of cow's milk protein allergy (CMPA). While extensively hydrolyzed formulas are commonly used to address these issues, the short-term efficacy of amino acid formulas (AAF) for managing colic remains understudied. This secondary analysis of a previously published prospective cohort, the largest of its kind in the United States, evaluated the short-term impact of AAF in improving colic and associated symptoms in infants under six months of age with suspected CMPA. This real-world prospective cohort study analyzed data from 138 infants with suspected CMPA initiated on AAF at Visit 1. After excluding 34 infants due to incomplete data or treatment changes, 104 infants were included in the final analysis. Symptom severity and resolution were assessed through outcomes across two visits, with care provided by general pediatricians (82%) and pediatric gastroenterologists (18%). At baseline, the most common symptoms were colic ( 83), gassiness ( 72), fussiness ( 66), and sleep disturbances ( 58). By the next follow-up visit (Visit 2), parents reported symptom improvements in colic (94%), gassiness (81%), fussiness (83%), and sleep disturbances (86%). Complete symptom resolution was observed in 73% of infants with colic, 68% with gassiness, 65% with fussiness, and 81% with sleep difficulties. By Visit 2, no infants had severe symptoms, with only mild residual symptoms reported. AAF was associated with significant short-term improvements in colic and related symptoms in infants with suspected CMPA. These preliminary findings highlight AAF as a promising dietary intervention during early infancy. Larger controlled studies are necessary to confirm these results and explore long-term outcomes.
婴儿功能性疾病，包括腹绞痛、易激惹和睡眠障碍，常常与牛奶蛋白过敏（CMPA）的症状重叠。虽然深度水解配方奶粉通常用于解决这些问题，但氨基酸配方奶粉（AAF）治疗腹绞痛的短期疗效仍未得到充分研究。这项对美国同类规模最大的已发表前瞻性队列研究的二次分析，评估了AAF对改善疑似CMPA的6个月以下婴儿腹绞痛及相关症状的短期影响。这项真实世界的前瞻性队列研究分析了138名在第1次就诊时开始使用AAF的疑似CMPA婴儿的数据。在排除34名因数据不完整或治疗改变的婴儿后，最终分析纳入了104名婴儿。症状严重程度和缓解情况通过两次就诊的结果进行评估，由普通儿科医生（82%）和儿科胃肠病学家（18%）提供护理。在基线时，最常见的症状是腹绞痛（83例）、肠胃气胀（72例）、烦躁不安（6例）和睡眠障碍（58例）。到下一次随访就诊（第2次就诊）时，家长报告腹绞痛（94%）、肠胃气胀（81%）、烦躁不安（83%）和睡眠障碍（86%）的症状有所改善。73%的腹绞痛婴儿、68%的肠胃气胀婴儿、65%的烦躁不安婴儿和81%的睡眠困难婴儿症状完全缓解。到第2次就诊时，没有婴儿出现严重症状，仅报告有轻微残留症状。AAF与疑似CMPA婴儿的腹绞痛及相关症状的显著短期改善相关。这些初步研究结果凸显了AAF作为婴儿早期一种有前景的饮食干预措施。需要更大规模的对照研究来证实这些结果并探索长期结局。
