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姜黄素:对抗炎症性肝病的天然斗士。

Curcumin: A Natural Warrior Against Inflammatory Liver Diseases.

作者信息

Obrzut Olga, Gostyńska-Stawna Aleksandra, Kustrzyńska Karolina, Stawny Maciej, Krajka-Kuźniak Violetta

机构信息

Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

出版信息

Nutrients. 2025 Apr 18;17(8):1373. doi: 10.3390/nu17081373.

Abstract

Curcumin (CUR), a bioactive compound found in turmeric, has garnered attention for its potential anti-inflammatory properties and impact on liver health. Numerous studies suggest that CUR may be crucial in mitigating liver inflammation. The compound's anti-inflammatory effects are believed to be attributed to its ability to modulate various molecular pathways involved in the inflammatory response. Research indicates that CUR may suppress the activation of inflammatory cells and the production of pro-inflammatory cytokines in the liver. Additionally, it has been observed to inhibit the activity of transcription factors that play a key role in inflammation. By targeting these molecular mechanisms, CUR may help alleviate the inflammatory burden on the liver. Moreover, CUR's antioxidant properties are thought to contribute to its protective effects on the liver. Oxidative stress is closely linked to inflammation, and CUR's ability to neutralize free radicals may further support its anti-inflammatory action. While the evidence is promising, it is essential to note that more research is needed to fully understand the precise mechanisms through which CUR influences liver inflammation. Nevertheless, these findings suggest that CUR could be a potential therapeutic agent in managing liver inflammatory conditions. In this review, we explore the potential impact of CUR on inflammation, highlighting the key mechanisms involved, as reported in the literature.

摘要

姜黄素(CUR)是姜黄中发现的一种生物活性化合物,因其潜在的抗炎特性及其对肝脏健康的影响而备受关注。大量研究表明,CUR可能在减轻肝脏炎症方面起着关键作用。该化合物的抗炎作用被认为归因于其调节参与炎症反应的各种分子途径的能力。研究表明,CUR可能会抑制肝脏中炎症细胞的激活和促炎细胞因子的产生。此外,据观察它还能抑制在炎症中起关键作用的转录因子的活性。通过靶向这些分子机制,CUR可能有助于减轻肝脏的炎症负担。此外,CUR的抗氧化特性被认为有助于其对肝脏的保护作用。氧化应激与炎症密切相关,CUR中和自由基的能力可能进一步支持其抗炎作用。虽然现有证据很有前景,但必须指出的是,需要更多的研究来充分了解CUR影响肝脏炎症的确切机制。然而,这些发现表明,CUR可能是治疗肝脏炎症性疾病的一种潜在治疗剂。在这篇综述中,我们探讨了CUR对炎症的潜在影响,突出了文献中报道的关键机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d3/12030243/98c079ec4593/nutrients-17-01373-g001.jpg

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