Jiang Shuai, Han Jing, Li Tian, Xin Zhenlong, Ma Zhiqiang, Di Wencheng, Hu Wei, Gong Bing, Di Shouyin, Wang Dongjin, Yang Yang
Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
Department of Ophthalmology, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an, 710038, China.
Pharmacol Res. 2017 May;119:373-383. doi: 10.1016/j.phrs.2017.03.001. Epub 2017 Mar 6.
Curcumin, which was first used 3000 years ago as an anti-inflammatory agent, is a well-known bioactive compound derived from the active ingredient of turmeric (Curcuma longa). Previous research has demonstrated that curcumin has immense therapeutic potential in a variety of diseases via anti-oxidative, anti-apoptotic, and anti-inflammatory pathways. Cardiac diseases are the leading cause of mortality worldwide and cause considerable harm to human beings. Numerous studies have suggested that curcumin exerts a protective role in the human body whereas its actions in cardiac diseases remain elusive and poorly understood. On the basis of the current evidence, we first give a brief introduction of cardiac diseases and curcumin, especially regarding the effects of curcumin in embryonic heart development. Secondly, we analyze the basic roles of curcumin in pathways that are dysregulated in cardiac diseases, including oxidative stress, apoptosis, and inflammation. Thirdly, actions of curcumin in different cardiac diseases will be discussed, as will relevant clinical trials. Eventually, we would like to discuss the existing controversial opinions and provide a detailed analysis followed by the remaining obstacles, advancement, and further prospects of the clinical application of curcumin. The information compiled here may serve as a comprehensive reference of the protective effects of curcumin in the heart, which is significant to the further research and design of curcumin analogs as therapeutic options for cardiac diseases.
姜黄素在3000年前就被用作抗炎剂，是一种从姜黄（Curcuma longa）的活性成分中提取的著名生物活性化合物。先前的研究表明，姜黄素通过抗氧化、抗凋亡和抗炎途径在多种疾病中具有巨大的治疗潜力。心脏病是全球主要的死亡原因，对人类造成了相当大的危害。许多研究表明，姜黄素在人体中发挥保护作用，但其在心脏病中的作用仍不明确且了解甚少。基于目前的证据，我们首先简要介绍心脏病和姜黄素，特别是姜黄素在胚胎心脏发育中的作用。其次，我们分析姜黄素在心脏病中失调的途径中的基本作用，包括氧化应激、细胞凋亡和炎症。第三，将讨论姜黄素在不同心脏病中的作用以及相关的临床试验。最后，我们将讨论现有的争议性观点，并进行详细分析，随后探讨姜黄素临床应用中存在的障碍、进展和进一步的前景。此处汇编的信息可作为姜黄素对心脏保护作用的综合参考，这对于进一步研究和设计姜黄素类似物作为心脏病的治疗选择具有重要意义。
