Silva Jessica, Azevedo Tiago, Aires Inês, Medeiros Catarina, Neuparth Maria J, Seixas Fernanda, Ferreira Rita, Faustino-Rocha Ana I, Oliveira Paula A, Duarte José Alberto
Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Vet Sci. 2025 Mar 26;12(4):303. doi: 10.3390/vetsci12040303.
Breast cancer remains a significant global health issue, affecting both humans and companion animals, particularly female dogs and cats, where mammary tumors are among the most common cancers. Strategies to minimize the impact of this disease on patients, pet owners, and veterinary medicine are essential. This study analyses the effects of resistance training on the development of chemically induced mammary cancer in female Wistar rats, divided into four groups: sedentary control (CTR), sedentary induced (CTR+-methyl--nitrosourea (MNU)), exercised control (EX), and exercised induced (EX+MNU). The exercise protocol involved ladder climbing three times a week for 18 weeks with the load progressively increasing. At the study's end, blood and histopathological samples were collected and analyzed. Although tumor onset occurred two weeks earlier and incidence was slightly higher in the exercised group (EX+MNU) compared to the control group (CTR+MNU), the mortality rate was lower, and the malignancy was not as aggressive. No systemic inflammation was observed, as the levels of albumin, C-reactive protein (CRP), and interleukin 6 (IL-6) in the MNU groups remained similar to the controls. Exercise has been shown to promote overall health by increasing physical fitness, boosting immunological function, and improving metabolic health. These findings may offer valuable insights into the potential role of resistance training in managing mammary cancer in companion animals. However, further research is required to assess clinical applicability and to establish safe and effective exercise protocols for veterinary oncology.
乳腺癌仍然是一个重大的全球健康问题，影响着人类和伴侣动物，尤其是雌性犬类和猫类，其中乳腺肿瘤是最常见的癌症之一。尽量减少这种疾病对患者、宠物主人和兽医学影响的策略至关重要。本研究分析了抗阻训练对雌性Wistar大鼠化学诱导性乳腺癌发生发展的影响，将其分为四组：久坐对照组（CTR）、久坐诱导组（CTR+甲基亚硝基脲（MNU））、运动对照组（EX）和运动诱导组（EX+MNU）。运动方案包括每周进行三次爬梯运动，持续18周，负荷逐渐增加。在研究结束时，收集并分析血液和组织病理学样本。虽然与对照组（CTR+MNU）相比，运动组（EX+MNU）的肿瘤发病提前了两周，发病率略高，但死亡率较低，恶性程度也没有那么高。未观察到全身炎症，因为MNU组的白蛋白、C反应蛋白（CRP）和白细胞介素6（IL-6）水平与对照组相似。运动已被证明可以通过提高身体素质、增强免疫功能和改善代谢健康来促进整体健康。这些发现可能为抗阻训练在伴侣动物乳腺癌管理中的潜在作用提供有价值的见解。然而，需要进一步研究以评估临床适用性，并为兽医肿瘤学建立安全有效的运动方案。
