Faustino-Rocha Ana I, Gama Adelina, Oliveira Paula A, Vanderperren Katrien, Saunders Jimmy H, Pires Maria J, Ferreira Rita, Ginja Mário
Faculty of Veterinary Medicine, Lusophone University of Humanities and Technologies, Lisbon, Portugal.
Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
J Ultrasound Med. 2017 Dec;36(12):2459-2466. doi: 10.1002/jum.14287. Epub 2017 Jun 24.
This study aimed to evaluate the impact of long-term exercise training on the vascularization of rat mammary tumors.
Female rats were divided into 4 groups: N-methyl-N-nitrosourea (MNU) treated sedentary, MNU treated exercised, control sedentary, and control exercised. Tumor development was induced in the MNU groups by MNU administration. Exercised groups were trained for 35 weeks. Tumor vascularization was evaluated by pulsed Doppler and contrast-enhanced ultrasonography.
The pulsatility and resistive indices were slightly higher in the MNU sedentary group (P > .05). Mammary tumors mainly had centripetal and heterogeneous enhancement of the contrast, clear margins, and the presence of penetrating vessels. The MNU exercised group had a lower arrival time and time to peak and higher peak intensity, wash-in, and wash-out (P > .05). The area under the curve was similar between groups (P > .05).
The contrast-enhanced ultrasonographic study did not detect differences in mammary tumor vascularization between MNU sedentary and MNU exercised groups previously detected by power Doppler imaging, B-flow imaging, and immunohistochemistry.
本研究旨在评估长期运动训练对大鼠乳腺肿瘤血管生成的影响。
将雌性大鼠分为4组：N-甲基-N-亚硝基脲（MNU）处理的久坐组、MNU处理的运动组、对照久坐组和对照运动组。MNU组通过给予MNU诱导肿瘤发生。运动组训练35周。通过脉冲多普勒和超声造影评估肿瘤血管生成。
MNU久坐组的搏动指数和阻力指数略高（P > 0.05）。乳腺肿瘤主要表现为造影剂向心性和不均匀增强、边界清晰以及存在穿支血管。MNU运动组的达峰时间和峰值时间较短，峰值强度、流入和流出较高（P > 0.05）。各组曲线下面积相似（P > 0.05）。
超声造影研究未发现MNU久坐组和MNU运动组之间乳腺肿瘤血管生成的差异，而之前通过能量多普勒成像、B-flow成像和免疫组化检测到了这种差异。
