Long Xuelin, Liu Shujun, Kang Runmin, Sun Yue, Tian Mingyue, Zhao Lijun, Lei Changwei, Wang Hongning, Yang Xin
Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China.
Sichuan Animal Science Academy, Chengdu 610066, China.
Vet Sci. 2025 Apr 9;12(4):345. doi: 10.3390/vetsci12040345.
Swine have emerged as significant reservoirs of antibiotic-resistant strains and genes. To establish a sound rationale for applying quinolone antibiotics in the swine industry, a meta-analysis was performed on the resistance rate of swine-derived to quinolone antibiotics in China from 2002 to 2022. We systematically searched through three databases, PubMed, Web of Science, and CNKI, and included 53 eligible studies within the specified timeframe. Resistance rates were calculated using a random-effects model and the Freeman-Tukey double-arcsine transformation. The resistance rates observed were as follows: 37% for levofloxacin (95% CI: 2747%), 43% for ofloxacin (95% CI: 3451%), 54% for enrofloxacin (95% CI: 4662%), and 50% for ciprofloxacin (95% CI: 4258%). Further subgroup analyses illuminated that the resistance rates were higher in mainland China's eastern regions than in western regions. Additionally, there was no significant decrease in the resistance rate over time in different periods. From 2002 to 2022, strains from swine in various regions of mainland China exhibited differing degrees of generalized resistance to quinolones. This poses a potential public health risk and underscores the fact that the control of quinolone antibiotics remains a prolonged and ongoing challenge.
猪已成为抗生素耐药菌株和基因的重要储存宿主。为了为喹诺酮类抗生素在养猪业中的应用建立合理依据，我们对2002年至2022年中国猪源菌株对喹诺酮类抗生素的耐药率进行了荟萃分析。我们系统地检索了三个数据库，即PubMed、Web of Science和中国知网，并纳入了指定时间范围内的53项符合条件的研究。耐药率采用随机效应模型和弗里曼-图基双反正弦变换进行计算。观察到的耐药率如下：左氧氟沙星为37%（95%置信区间：27%47%），氧氟沙星为43%（95%置信区间：34%51%），恩诺沙星为54%（95%置信区间：46%62%），环丙沙星为50%（95%置信区间：42%58%）。进一步的亚组分析表明，中国大陆东部地区的耐药率高于西部地区。此外，不同时期的耐药率并未随时间显著下降。2002年至2022年，中国大陆各地区猪的菌株对喹诺酮类药物表现出不同程度的广泛耐药性。这带来了潜在的公共卫生风险，并凸显了一个事实，即喹诺酮类抗生素的控制仍然是一项长期且持续的挑战。
