Pereira Santos Vanessa Emanuelle, de França São Marcos Bianca, Fontes Pedro Henrique Bezerra, Silva Micaela Evellin Dos Santos, Leão Stephanie Loureiro, da Silva Gabriel Rômulo Parente, Ribeiro Davi Emanuel, da Gama Marco Antonio Turiah Machado, de Oliveira Isídio Beatriz Eda, de Moura Ingrid Andrêssa, Lussón David Beltrán, Leal Lígia Rosa Sales, Venuti Aldo, Freitas Antonio Carlos de
Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., 50670-901 Pernambuco, Brazil.
HPV-Unit, UOSD Tumor Immunology and Immunotherapy IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Viruses. 2025 Apr 1;17(4):512. doi: 10.3390/v17040512.
Head and neck cancer (HNC) is the sixth most prevalent type of cancer worldwide and is associated with low five-year survival rates. Alcoholism and smoking are the main risk factors associated with the development of head and neck cancer (HNC). However, Human Papillomavirus (HPV) infection has been reported as a significant risk factor, particularly for the oropharyngeal subset. In these cases, patients with HPV-positive HNC exhibit a better clinical prognosis; however, resistance to chemotherapy has been frequently reported. The carcinogenic activity of HPV is related to the viral oncoproteins E5, E6, and E7. E5 has been associated with immune evasion mechanisms and modulation of the tumor microenvironment, which appears to be linked to the virus's resistance to chemotherapeutic treatments. Here, we review the potential of HPV E5 in targeted therapy for HNC and discuss relevant data regarding the activity of this oncoprotein in head and neck carcinogenesis.
头颈癌（HNC）是全球第六大常见癌症类型，且五年生存率较低。酗酒和吸烟是与头颈癌（HNC）发生相关的主要风险因素。然而，据报道，人乳头瘤病毒（HPV）感染是一个重要的风险因素，特别是对于口咽亚组。在这些病例中，HPV阳性的头颈癌患者表现出较好的临床预后；然而，化疗耐药情况也屡有报道。HPV的致癌活性与病毒癌蛋白E5、E6和E7有关。E5与免疫逃逸机制以及肿瘤微环境的调节有关，这似乎与该病毒对化疗治疗的耐药性有关。在此，我们综述了HPV E5在头颈癌靶向治疗中的潜力，并讨论了有关该癌蛋白在头颈癌发生过程中活性的相关数据。
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