McGowan H, Anderson H, Barden A, Vandongen R
Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):253-6. doi: 10.1111/j.1440-1681.1985.tb02642.x.
Renal denervation of hypertensive one-kidney, one-clip (1K, 1C) rats resulted in a minor fall in blood pressure (216, s.e.m. = 4, to 182, s.e.m. = 4, mmHg) 24 h later, which returned to predenervation levels with 1 week. Subsequent unclipping led to a similar fall in blood pressure in denervated (202, s.e.m. = 4 to 142, s.e.m. = 3) and sham-denervated (211, s.e.m. = 5 to 147, s.e.m. = 4) rats. Unclipping also resulted in a marked rise in urinary PGE2 and 6-keto PFG1 alpha in both denervated and sham-denervated animals. It appears that 1K, 1C hypertension, 8 weeks after clipping, is only slightly dependent on renal nerves. Unclipping results in increased renal synthesis of PGE2 and PGI2 which is not dependent on intact renal innervation.
对高血压单肾单夹（1K，1C）大鼠进行肾去神经支配后，24小时后血压略有下降（从216，标准误=4，降至182，标准误=4，mmHg），但1周后又恢复到去神经支配前的水平。随后松开夹子，去神经支配的大鼠（从202，标准误=4降至142，标准误=3）和假去神经支配的大鼠（从211，标准误=5降至147，标准误=4）血压出现类似下降。松开夹子还导致去神经支配和假去神经支配的动物尿中前列腺素E2（PGE2）和6-酮前列腺素F1α（6-keto PFG1 alpha）显著升高。似乎夹闭8周后的1K，1C高血压仅轻微依赖肾神经。松开夹子会导致肾脏中PGE2和前列环素（PGI2）合成增加，且这一过程不依赖完整的肾神经支配。
