Wyss J M, Aboukarsh N, Oparil S
Am J Physiol. 1986 Jan;250(1 Pt 2):H82-6. doi: 10.1152/ajpheart.1986.250.1.H82.
To determine the role of the renal afferent nerves in the pathogenesis of one-kidney, one-clip renovascular hypertension, the renal afferent nerves were selectively lesioned by dorsal rhizotomy, a procedure that eliminates renal sensory input to the spinal cord but does not directly damage the sympathomotor innervation of the kidney. One week after denervation, the proximal left renal artery was clipped in denervated and sham control rats. Blood pressure of the sham group rose progressively over the next 5 wk, to 185 mmHg (systolic). In contrast, blood pressure of the denervated rats leveled off in the borderline hypertensive range, a level significantly lower than that of the sham group but significantly higher than that of non-clipped rats. In two further experiments the specificity of this effect was demonstrated. Lesion of the dorsal root nerves on the side of nephrectomy did not significantly lower blood pressure of non-clipped rats, and contralateral dorsal rhizotomy did not lower the blood pressure of clipped rats. These results demonstrate that the renal afferent nerves significantly contribute to one-kidney, one-clip renovascular hypertension in the rat.
为了确定肾传入神经在一侧肾、一侧肾动脉夹闭型肾血管性高血压发病机制中的作用，采用背根切断术选择性地损伤肾传入神经，该手术可消除肾脏向脊髓的感觉输入，但不会直接损害肾脏的交感运动神经支配。去神经支配一周后，对去神经支配的大鼠和假手术对照大鼠夹闭左肾动脉近端。假手术组的血压在接下来的5周内逐渐升高，达到185 mmHg（收缩压）。相比之下，去神经支配大鼠的血压在临界高血压范围内趋于平稳，该水平显著低于假手术组，但显著高于未夹闭肾动脉的大鼠。在另外两个实验中证实了这种效应的特异性。肾切除侧的背根神经损伤并未显著降低未夹闭肾动脉大鼠的血压，对侧背根切断术也未降低夹闭肾动脉大鼠的血压。这些结果表明，肾传入神经在大鼠一侧肾、一侧肾动脉夹闭型肾血管性高血压中起重要作用。
