Puddey I B, Beilin L J, Vandongen R, Rouse I L
Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):257-61. doi: 10.1111/j.1440-1681.1985.tb02643.x.
Forty-six healthy normotensive male drinkers participated in a randomized, controlled, crossover trial to study the effects of varying alcohol intake on blood pressure. Alcohol consumption (calculated from weekly diaries) was reduced from 336.3 (s.e.m. = 20.2) to 64.5 (s.e.m. = 5.6) ml ethanol/week by drinking low alcohol content beer alone. Systolic blood pressure fell significantly during reduction of alcohol intake and rose again when normal drinking habits were resumed, the mean difference during the last 2 weeks of normal or low alcohol intake being 3.8 mmHg. This effect of alcohol on blood pressure was independent of a small but significant decrease in weight following reduction of alcohol intake. The change in blood pressure correlated with change in alcohol consumption (r = 0.53, P less than 0.001) with a 1 mmHg fall predicted for each 100 ml of reduction in ethanol intake/week. We conclude that regular moderate alcohol consumption has a direct (but reversible) pressor effect in normotensive men.
46名健康的血压正常男性饮酒者参与了一项随机、对照、交叉试验，以研究不同饮酒量对血压的影响。仅通过饮用低酒精含量啤酒，酒精摄入量（根据每周记录计算）从336.3（标准误=20.2）降至64.5（标准误=5.6）毫升乙醇/周。在减少酒精摄入期间，收缩压显著下降，恢复正常饮酒习惯时又再次上升，正常或低酒精摄入的最后2周期间的平均差异为3.8 mmHg。酒精对血压的这种影响与减少酒精摄入后体重的小幅但显著下降无关。血压变化与酒精摄入量变化相关（r = 0.53，P<0.001），预计每周乙醇摄入量每减少100毫升，血压下降1 mmHg。我们得出结论，规律适度饮酒对血压正常的男性有直接（但可逆）的升压作用。
