Musgrave I F, Bachmann A W, Jackson R V, Gordon R D
Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):285-9. doi: 10.1111/j.1440-1681.1985.tb02647.x.
Both resting and stimulated (straight-leg raising and head-up tilt) levels of arterial and venous plasma noradrenaline were significantly higher during low-dose adrenaline infusion in five mild hypertensive and four normotensive patients with one adrenal. Repeat adrenaline infusions in the five hypertensive patients while measuring noradrenaline clearance (3H-noradrenaline constant infusion) achieved similar levels of plasma adrenaline, and similar increases in plasma noradrenaline, within five min of achieving target infusion rate. Increased plasma noradrenaline was not explained by reduced clearance. These results are consistent with the hypothesis that physiological concentrations of adrenaline are capable of facilitating noradrenaline release in man.
在五名轻度高血压患者和四名有一个肾上腺的血压正常患者中，低剂量肾上腺素输注期间，动脉和静脉血浆去甲肾上腺素的静息水平和刺激水平（直腿抬高和头高位倾斜）均显著升高。在五名高血压患者中重复进行肾上腺素输注，同时测量去甲肾上腺素清除率（3H-去甲肾上腺素持续输注），在达到目标输注速率的五分钟内，血浆肾上腺素水平相似，血浆去甲肾上腺素也有相似的升高。血浆去甲肾上腺素升高并非由清除率降低所致。这些结果与肾上腺素的生理浓度能够促进人体去甲肾上腺素释放这一假说相符。
