Saar N, Jackson R, Bachmann A, Gordon R
Prog Biochem Pharmacol. 1980;17:90-7.
Levels of noradrenaline, adrenaline and dopamine were measured simultaneously from different sites, during stimulation and during noradrenaline infusion. Levels of the three catecholamines were similar in low inferior vena cava and a forearm vein. The ratio between adrenal venous and peripheral levels averaged 49:1 for adrenaline but only 4:1 for noradrenaline, consistent with other significant sources for noradrenaline apart from the adrenal. Levels of dopamine were only slightly higher in adrenal venous blood, consistent with the adrenal being a minor source in these subjects. Forearm arteriovenous differences for adrenaline and noradrenaline demonstrated significant removal of these amines across this vascular bed. To monitor sympathetic responses, venous noradrenaline appears satisfactory, but venous adrenaline would miss responses detected by arterial levels. Sympathetic responses were not reflected by changes in either arterial or venous dopamine.
在刺激过程中和去甲肾上腺素输注期间，同时从不同部位测量去甲肾上腺素、肾上腺素和多巴胺的水平。在下腔静脉低位和前臂静脉中，这三种儿茶酚胺的水平相似。肾上腺静脉与外周水平的肾上腺素平均比值为49:1，但去甲肾上腺素仅为4:1，这与除肾上腺外去甲肾上腺素的其他重要来源一致。肾上腺静脉血中多巴胺水平仅略高，这与肾上腺是这些受试者的次要来源一致。肾上腺素和去甲肾上腺素在前臂动静脉的差异表明，这些胺类物质在此血管床中被大量清除。为监测交感神经反应，静脉去甲肾上腺素似乎令人满意，但静脉肾上腺素会遗漏动脉水平检测到的反应。动脉或静脉多巴胺的变化均未反映交感神经反应。
