Yang Hanxue, Rong Chao, Ge Shundong, Wang Tao, Zhang Bowei, Xuan Fu-Zhen
Shanghai Key Laboratory of Intelligent Sensing and Detection Technology, East China University of Science and Technology, Shanghai 200237, China.
Key Laboratory of Pressure Systems and Safety of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
Sensors (Basel). 2025 Apr 16;25(8):2508. doi: 10.3390/s25082508.
Simultaneous detection of dopamine (DA) and uric acid (UA) is essential for diagnosing neurological and metabolic diseases but hindered by overlapping electrochemical signals. We present an ultrasensitive electrochemical sensor using copper nanoclusters anchored on nitrogen-doped crumpled TiCT MXene (Cu-N/TiCT). The engineered 3D crumpled architecture prevents MXene restacking, exposes active sites, and enhances ion transport, while Cu nanoclusters boost electrocatalytic activity via accelerated electron transfer. Structural analyses confirm uniform Cu dispersion (3.0 wt%), Ti-N bonding, and strain-induced wrinkles, synergistically improving conductivity. The sensor achieves exceptional sensitivity (1958.3 and 1152.7 μA·mM·cm for DA/UA), ultralow detection limits (0.058 and 0.099 μM for DA/UA), rapid response (<1.5 s), and interference resistance (e.g., ascorbic acid). Differential pulse voltammetry enables independent linear detection ranges (DA: 2-60 μM; UA: 5-100 μM) in biofluids, with 94.4% stability retention over 7 days. The designed sensor exhibits excellent capabilities for DA and UA detection. This work provides a novel design strategy for developing high-performance electrochemical sensors.
同时检测多巴胺（DA）和尿酸（UA）对于诊断神经和代谢疾病至关重要，但受到重叠电化学信号的阻碍。我们展示了一种超灵敏的电化学传感器，它使用锚定在氮掺杂的皱缩TiCT MXene（Cu-N/TiCT）上的铜纳米团簇。设计的三维皱缩结构可防止MXene重新堆叠，暴露出活性位点，并增强离子传输，而铜纳米团簇则通过加速电子转移提高电催化活性。结构分析证实了铜的均匀分散（3.0 wt%）、Ti-N键合和应变诱导的皱纹，协同提高了导电性。该传感器实现了出色的灵敏度（DA/UA分别为1958.3和1152.7 μA·mM·cm）、超低检测限（DA/UA分别为0.058和0.099 μM）、快速响应（<1.5 s）和抗干扰能力（如抗坏血酸）。差分脉冲伏安法能够在生物流体中实现独立的线性检测范围（DA：2-60 μM；UA：5-100 μM），在7天内稳定性保持率为94.4%。所设计的传感器在检测DA和UA方面表现出优异的能力。这项工作为开发高性能电化学传感器提供了一种新颖的设计策略。
