Ademe Sewunet, Mohammed Tariku, Edmealem Afework, Tegegne Belachew, Bewket Bekalu, Andualem Atsedemariam, Bires Abebaw
College of Medicine and Health Science, Department of Nursing, Injibara University, Injibara, Ethiopia.
Tropical College of Medicine, Dessie, Ethiopia.
Discov Oncol. 2025 Apr 26;16(1):619. doi: 10.1007/s12672-025-02063-8.
Adherence to chemotherapy treatment requires collaboration and sincere agreement between healthcare providers and patients. Poor medication adherence is problematic as it can lead to reduced effectiveness of the treatment. Poor survival, a rise in relapses, treatment failure, and higher healthcare expenses will result from this. A measure of patient treatment adherence is crucial to attain ideal results, such as curative treatment or improving quality of life.
To assess cancer patients' adherence to chemotherapy and related factors patients in the Amhara Region, Ethiopia, in 2022.
Between May 28, 2022, and June 22, 2022, 460 cancer patients in the Amhara region participated in a cross-sectional study carried out by systematic randomized sampling. Data were gathered using an interview-based, previously approved questionnaire. For analysis, the data were first imported into Epi-Data version 4.6 and then exported to the Statistical Package for Social Science version 26. Variables with a p-value of 0.25 were evaluated in a bivariate logistic regression to select a candidate variable for multivariate logistic regression. Variables with a p-value less than 0.05 were deemed significantly associated factors in multivariable logistic regression, and the resulting AOR and 95% CI are displayed for those variables. The Hosmer Lemeshow test was used to confirm the model's appropriateness, and multi-collinearity was verified with a standard error.
The proportion of good adherence in the Amhara region is 42.3% (95%CI [37.6-47.6]). A history of comorbidity [AOR = 2.74, 95% CI (1.56, 4.81)], no serious side effects from chemotherapy [AOR = 3.50, 95% CI (1.55, 7.90)], having social support [AOR = 1.52, 95% CI (1.21, 1.95)], being a woman [AOR = 2.17, 95% CI (1.31, 3.60)], and having a family history of cancer [AOR = 3.58, 95% CI (2.22, 5.76)], were associated with good chemotherapy adherence.
Compared to other studies, the proportion of poor adherence in the Amhara region was high. Health professionals, families, and government representatives should all work together to provide social support and other systems that will lessen the likelihood that cancer patients with comorbidities may have side effects from chemotherapy.
坚持化疗需要医疗服务提供者与患者之间的合作与真诚共识。用药依从性差是个问题，因为这会导致治疗效果降低。由此将导致生存率降低、复发率上升、治疗失败以及医疗费用增加。衡量患者治疗依从性对于取得理想结果（如治愈性治疗或改善生活质量）至关重要。
评估2022年埃塞俄比亚阿姆哈拉地区癌症患者对化疗的依从性及相关因素。
2022年5月28日至2022年6月22日期间，阿姆哈拉地区的460名癌症患者参与了一项通过系统随机抽样进行的横断面研究。使用基于访谈的、先前已批准的问卷收集数据。为进行分析，数据首先导入Epi-Data 4.6版本，然后导出到社会科学统计软件包26版本。在双变量逻辑回归中评估p值为0.25的变量，以选择多变量逻辑回归的候选变量。在多变量逻辑回归中，p值小于0.05的变量被视为显著相关因素，并显示这些变量的结果比值比（AOR）和95%置信区间（CI）。使用Hosmer Lemeshow检验来确认模型的适用性，并通过标准误差验证多重共线性。
阿姆哈拉地区依从性良好的比例为42.3%（95%CI[37.6 - 47.6]）。合并症病史[AOR = 2.74，95%CI（1.56，4.81）]、化疗无严重副作用[AOR = 3.50，95%CI（1.
