Li Fanglin, Pang Shuqin, Hao Shiqi, Liu Yuanyuan, Lei Wenwen, Zhong Wenying, Xu Keming
Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, China.
Int J Biol Macromol. 2025 May;310(Pt 4):143480. doi: 10.1016/j.ijbiomac.2025.143480. Epub 2025 Apr 24.
Acne vulgaris is a common chronic inflammatory skin disorder primarily caused by the overgrowth of Propionibacterium acnes (P. acnes). However, the therapeutic efficacy of traditional drugs is often limited due to their inability to penetrate the stratum corneum. Microneedles (MNs) are designed to penetrate the stratum corneum, enabling direct drug delivery to the epidermis. In this study, a new Dendrobium polysaccharide-based composite microneedle (DOP/CCF/PLGA@Adap-MN) delivery system was developed. Dendrobium polysaccharide (DOP) was utilized as the microneedle matrix, loaded with the Celosia cristata flavonoids (CCF) and poly(lactic-co-glycolic acid) adapalene nanoparticles (PLGA@Adap NPs). DOP not only enhanced the mechanical properties and transdermal efficiency of the microneedles but also provided intrinsic anti-inflammatory activity. CCF effectively inhibited the growth of P. acnes, while PLGA@Adap NPs slowly released adapalene to promote acne healing. In vivo studies using a P. acnes-induced mice model demonstrated that this microneedle system effectively reduced skin swelling, inhibited bacterial growth, and decreased inflammatory cell numbers in the skin. The use of bioactive DOP as a microneedle matrix, combined with sustained-release technology, provides a multifaceted and synergistic approach to acne treatment.
寻常痤疮是一种常见的慢性炎症性皮肤病，主要由痤疮丙酸杆菌（P. acnes）过度生长引起。然而，传统药物的治疗效果往往有限，因为它们无法穿透角质层。微针（MNs）旨在穿透角质层，实现药物直接递送至表皮。在本研究中，开发了一种新型的基于铁皮石斛多糖的复合微针（DOP/CCF/PLGA@Adap-MN）递送系统。铁皮石斛多糖（DOP）用作微针基质，负载鸡冠花黄酮（CCF）和聚乳酸-羟基乙酸共聚物阿达帕林纳米颗粒（PLGA@Adap NPs）。DOP不仅增强了微针的机械性能和透皮效率，还具有内在的抗炎活性。CCF有效抑制痤疮丙酸杆菌的生长，而PLGA@Adap NPs缓慢释放阿达帕林以促进痤疮愈合。使用痤疮丙酸杆菌诱导的小鼠模型进行的体内研究表明，这种微针系统有效地减轻了皮肤肿胀，抑制了细菌生长，并减少了皮肤中的炎症细胞数量。使用具有生物活性的DOP作为微针基质，并结合缓释技术，为痤疮治疗提供了一种多方面的协同方法。
