Ribeiro Lívia, Fischer Bruna Venzke, Vitali Filipe Colombo, Santos Pablo Silveira, Teixeira Cleonice da Silveira, Queiroz Índia Olinta de Azevedo, Sivieri-Araujo Gustavo, Dos Santos Paulo Henrique, Garcia Lucas da Fonseca Roberti
Department of Dentistry - Endodontics Division, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Department of Dentistry - Endodontics Division, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
J Dent. 2025 Jul;158:105783. doi: 10.1016/j.jdent.2025.105783. Epub 2025 Apr 24.
This scoping review explores advancements in integrating laser technologies into regenerative endodontic procedures (REPs) and evaluates their potential benefits compared to conventional approaches.
The review encompassed searches in electronic databases - Embase, Cochrane Library, PubMed, Scopus, and Web of Science (September 27th, 2024) - and grey literature from Google Scholar and ProQuest.
Out of 480 identified references, 14 studies met the inclusion criteria. Laser applications were categorized into photobiomodulation (PBM), photodynamic therapy (PDT), and other laser-assisted techniques, such as Er:YAG laser-assisted irrigation and diode laser dentin etching. PBM showed enhanced tissue regeneration through improved angiogenesis, cell proliferation, and the release of growth factors such as TGF-β1. PDT provided antimicrobial effects without compromising cell viability. Er:YAG laser-assisted irrigation demonstrated increased growth factor release but posed risks of irrigant extrusion. Additionally, diode laser dentin etching enhanced stem cell attachment, offering improvements to REPs.
With an expanding evidence base, laser technologies hold promise for becoming integral to REPs, enabling minimally invasive and effective treatments for necrotic and traumatized immature teeth. Nonetheless, the limited number of studies highlights the need for further research. Standardized clinical trials are crucial to establish long-term outcomes and address safety concerns.
REPs offer a promising approach for treating immature necrotic teeth, and the use of lasers in endodontics has demonstrated advantages over traditional methods. This scoping review aimed to explore significant findings regarding the use of laser-assisted therapies in REPs.
本综述探讨了将激光技术整合到再生性牙髓治疗程序（REPs）中的进展，并评估了其与传统方法相比的潜在益处。
该综述涵盖了在电子数据库（Embase、Cochrane图书馆、PubMed、Scopus和科学网，检索时间为2024年9月27日）以及来自谷歌学术和ProQuest的灰色文献中的搜索。
在480篇已识别的参考文献中，有14项研究符合纳入标准。激光应用被分为光生物调节（PBM）、光动力疗法（PDT）以及其他激光辅助技术，如铒：钇铝石榴石（Er:YAG）激光辅助冲洗和二极管激光牙本质蚀刻。PBM通过改善血管生成、细胞增殖以及释放如转化生长因子-β1（TGF-β1）等生长因子，显示出增强的组织再生能力。PDT具有抗菌作用且不影响细胞活力。Er:YAG激光辅助冲洗显示出生长因子释放增加，但存在冲洗剂挤出的风险。此外，二极管激光牙本质蚀刻增强了干细胞附着，为REPs带来了改善。
随着证据基础的不断扩大，激光技术有望成为REPs不可或缺的一部分，为坏死和外伤的未成熟牙齿提供微创且有效的治疗。尽管如此，研究数量有限凸显了进一步研究的必要性。标准化的临床试验对于确定长期疗效和解决安全问题至关重要。
REPs为治疗未成熟坏死牙齿提供了一种有前景的方法，并且在牙髓病学中使用激光已显示出优于传统方法的优势。本综述旨在探讨关于在REPs中使用激光辅助治疗的重要发现。
