载药吲哚菁绿J聚集体激活金属免疫疗法用于肝细胞癌的持续光热治疗

Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma.

作者信息

He Kaiming, Chen Desheng, Zhu Dongzi, Zheng Wenjie, Lyu Lei, Zhang Mingshen, Chen Zeping, Wang Xiaowen, Hu Yongwei, Fu Binsheng

机构信息

Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute of Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, 510630, China.

Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

出版信息

J Nanobiotechnology. 2025 Apr 26;23(1):317. doi: 10.1186/s12951-025-03353-7.

Hepatocellular carcinoma (HCC) poses a significant therapeutic challenge, driving the need for novel treatment strategies. This study investigates the combination of photothermal therapy (PTT) and metalloimmunotherapy for HCC treatment using Co + diABZI@J-dICG nanoparticles. Indocyanine green (ICG), an FDA-approved near-infrared (NIR) dye, is dimerized into J-aggregates to enhance PTT by improving light absorption and photothermal efficiency. The cGAS-STING pathway, a key mediator of innate immunity, is activated by the STING agonist diABZI, while cobalt ions (Co) further enhance immune responses. The Co + diABZI@J-dICG nanoparticles take advantage of ICG's hepatotropic properties for sustained tumor accumulation and immune activation, resulting in significant tumor growth inhibition and reduced HCC recurrence following hepatectomy.

肝细胞癌（HCC）带来了重大的治疗挑战，这促使人们需要新的治疗策略。本研究调查了使用Co + diABZI@J-dICG纳米颗粒将光热疗法（PTT）和金属免疫疗法联合用于HCC治疗的效果。吲哚菁绿（ICG）是一种经美国食品药品监督管理局（FDA）批准的近红外（NIR）染料，它二聚形成J聚集体，通过提高光吸收和光热效率来增强PTT。天然免疫的关键介质cGAS-STING通路可被STING激动剂diABZI激活，而钴离子（Co）可进一步增强免疫反应。Co + diABZI@J-dICG纳米颗粒利用ICG的亲肝特性实现肿瘤的持续积累和免疫激活，从而显著抑制肿瘤生长，并降低肝切除术后HCC的复发率。