School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, United Kingdom; Department of Pharmaceutics, College of Pharmacy, Northern Border University, Arar 91431, Saudi Arabia.
School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, United Kingdom; China Medical University and Queen's University Joint College, Shenyang, People's Republic of China.
Int J Pharm. 2024 Aug 15;661:124456. doi: 10.1016/j.ijpharm.2024.124456. Epub 2024 Jul 8.
Indocyanine green is an FDA-approved fluorescent imaging dye used for determining cardiac output, hepatic function, liver blood flow, and retinal perfusion. It has been investigated preclinically in photoacoustic imaging and photothermal therapy (PTT); however, ICG photodegradation limits its biomedical applications. An aggregated form of ICG, known as J-aggregate (IJA), exhibits superior photoacoustic signals and thermal stability than the monomeric ICG. Nevertheless, IJA still suffers from low stability in the biological milieu, and short in vivo blood circulation. To address these limitations, a range of nanocarriers have been developed to enhance IJA stability and performance. This review focuses on IJA potentials and limitations, besides the recent development of IJA-loaded nanocarriers, particularly for cancer imaging and therapy.
吲哚菁绿是一种获得 FDA 批准的荧光成像染料，用于测定心输出量、肝功能、肝血流量和视网膜灌注。它已在光声成像和光热治疗（PTT）中进行了临床前研究；然而，ICG 的光降解限制了其在生物医学中的应用。ICG 的一种聚集形式，称为 J-聚集（IJA），比单体 ICG 具有更优异的光声信号和热稳定性。然而，IJA 仍然在生物环境中稳定性差，体内血液循环时间短。为了解决这些限制，已经开发了一系列纳米载体来增强 IJA 的稳定性和性能。本综述重点介绍了 IJA 的潜力和局限性，以及最近载有 IJA 的纳米载体的发展，特别是用于癌症成像和治疗。
