Samsoondar W, Freeman J B
Crit Care Med. 1985 Sep;13(9):753-5. doi: 10.1097/00003246-198509000-00013.
This randomized prospective study of all invasive catheters inserted in our ICU tested the hypothesis that daily dressing changes would reduce the 25% infection rate associated with these catheters. Significant growth was noted in eight (7%) of 133 vs. nine (6.7%) of 135 skin cultures from patients whose dressings and infusion tubings were changed at 24 vs. 72 h, respectively. Catheter tip cultures were positive in six (5.9%) of 102 vs. eight (7.5%) of 107 for the 24- and 72-h groups, respectively. Paradoxically, blood cultures were positive in three (6.7%) of 45 vs. 12 (23.1%) of 52 from the 24- and 72-h groups, respectively (p less than .03). However, there was no correlation between the positive blood cultures and the organisms cultured from the catheter tips.
这项针对我们重症监护病房（ICU）内所有插入的侵入性导管的随机前瞻性研究，检验了每日更换敷料会降低与这些导管相关的25%感染率这一假设。在分别于24小时和72小时更换敷料及输液管的患者中，133份皮肤培养样本中有8份（7%）出现显著菌生长，而135份皮肤培养样本中有9份（6.7%）出现显著菌生长。对于24小时组和72小时组，导管尖端培养分别在102份样本中有6份（5.9%）呈阳性，在107份样本中有8份（7.5%）呈阳性。矛盾的是，血培养在24小时组的45份样本中有3份（6.7%）呈阳性，而在72小时组的52份样本中有12份（23.1%）呈阳性（p小于0.03）。然而，血培养阳性与从导管尖端培养出的微生物之间没有相关性。
