Nair Abhilash Vijay, Singh Anmol, Chakravortty Dipshikha
Department of Microbiology and Cell Biology, Division of Biological Sciences, Indian Institute of Science, Bengaluru, India.
Department of Microbiology and Cell Biology, Division of Biological Sciences, Indian Institute of Science, Bengaluru, India; Adjunct Faculty, School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, India.
Redox Biol. 2025 Jun;83:103648. doi: 10.1016/j.redox.2025.103648. Epub 2025 Apr 21.
Microbial infections have been a widely studied area of disease research since historical times, yet they are a cause of severe illness and deaths worldwide. Furthermore, infections by pathogens are not just restricted to humans; instead, a diverse range of hosts, including plants, livestock, marine organisms and fish, cause significant economic losses and pose threats to humans through their transmission in the food chain. It is now believed that both the pathogen and the host contribute to the outcomes of a disease pathology. Researchers have unravelled numerous aspects of host-pathogen interactions, offering valuable insights into the physiological, cellular and molecular processes and factors that contribute to the development of infectious diseases. Polyamines are key factors regulating cellular processes and human ageing and health. However, they are often overlooked in the context of host-pathogen interactions despite playing a dynamic role as a defence molecule from the perspective of the host as well as the pathogen. They form a complex network interacting with several molecules within the cell, with reactive oxygen species being a key component. This review presents a thorough overview of the current knowledge of polyamines and their intricate interactions with reactive oxygen species in the infection of multiple pathogens in diverse hosts. Interestingly, the review covers the interplay of the commensals and pathogen infection involving polyamines and reactive oxygen species, highlighting an unexplored area within this field. From a future perspective, the dynamic interplay of polyamines and oxidative stress in microbial pathogenesis is a fascinating area that widens the scope of developing therapeutic strategies to combat deadly infections.
自历史以来，微生物感染一直是疾病研究中一个广泛研究的领域，但它们在全球范围内仍是严重疾病和死亡的一个原因。此外，病原体感染不仅限于人类；相反，包括植物、家畜、海洋生物和鱼类在内的各种各样的宿主，会造成重大经济损失，并通过食物链传播对人类构成威胁。现在人们认为，病原体和宿主都对疾病病理的结果有影响。研究人员已经揭示了宿主与病原体相互作用的许多方面，为有助于传染病发展的生理、细胞和分子过程及因素提供了宝贵的见解。多胺是调节细胞过程以及人类衰老和健康的关键因素。然而，尽管从宿主和病原体的角度来看，它们作为一种防御分子发挥着动态作用，但在宿主与病原体相互作用的背景下，它们常常被忽视。它们形成了一个与细胞内多种分子相互作用的复杂网络，其中活性氧是关键组成部分。本综述全面概述了目前关于多胺及其在多种宿主中多种病原体感染过程中与活性氧的复杂相互作用的知识。有趣的是，该综述涵盖了共生菌与病原体感染之间涉及多胺和活性氧的相互作用，突出了该领域内一个未被探索的领域。从未来的角度来看，多胺与氧化应激在微生物发病机制中的动态相互作用是一个引人入胜的领域，拓宽了开发对抗致命感染治疗策略的范围。
