Li Kaixi, Li Nan, Chen Yuanyuan, Li Xiangyu, Qiao Yanling, Wang Dan, Di Bin, Xu Peng
School of Pharmacy, China Pharmaceutical University, Nanjing, China; Office of China National Narcotics Control Commission, China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Beijing, China.
School of Pharmacy, China Pharmaceutical University, Nanjing, China; Beijing Regional Center of National Narcotics Laboratory, Beijing, China; Office of China National Narcotics Control Commission, China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Beijing, China.
Neurosci Res. 2025 Jul;216:104903. doi: 10.1016/j.neures.2025.04.006. Epub 2025 Apr 25.
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT receptor is the key receptor for hallucinogenic effects. In the present study, the monoamine neurotransmitters DA and its metabolites 3,4-Dihydroxyphenylacetic Acid (DOPAC) and homovanillic acid (HVA), 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were systematically investigated in the prefrontal cortex (PFC), nucleus accumbent (NAc), dorsolateral striatum (DLS) and hippocampus (HIP) using a validated HPLC-ECD analytical method after administration of the three tryptamines at different doses. The results showed that the three tryptamines had certain effects and the effects were different in different brain regions and showed that AMT, 5-MeO-AMT and 5-MeO-DiPT had significant effects on monoaminergic neurotransmitters in rat brains. Among them, DAergic and serotonergic play important roles, and this study provides valuable information for further research on the neurochemical effects of tryptamine hallucinogens in the brain.
α-甲基色胺（AMT）、5-甲氧基-α-甲基色胺（5-MeO-AMT）和5-甲氧基-N,N-二异丙基色胺（5-MeO-DiPT）是三种具有致幻特性的合成色胺，在全球范围内被广泛滥用。色胺的致幻作用主要与5-羟色胺（5-HT）受体的激活有关，在5-HT受体的众多亚型中，5-HT受体是产生致幻作用的关键受体。在本研究中，使用经过验证的高效液相色谱-电化学检测（HPLC-ECD）分析方法，在给予不同剂量的三种色胺后，系统研究了前额叶皮质（PFC）、伏隔核（NAc）、背外侧纹状体（DLS）和海马体（HIP）中的单胺类神经递质多巴胺（DA）及其代谢产物3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）、5-HT及其代谢产物5-羟吲哚乙酸（5-HIAA）。结果表明，这三种色胺具有一定作用，且在不同脑区作用不同，表明AMT、5-MeO-AMT和5-MeO-DiPT对大鼠脑中的单胺能神经递质有显著影响。其中，多巴胺能和5-羟色胺能起重要作用，本研究为进一步研究色胺致幻剂在脑中的神经化学作用提供了有价值的信息。
